{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:00:25Z","timestamp":1787500825067,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Self Assessment Vitiligo Extent Score (SA\u2010VES) is a validated, patient\u2010reported outcome measure to assess the body surface area affected with vitiligo. Information on how to translate the obtained score into extent, severity and impact strata (mild\u2013moderate\u2013severe) is still lacking. Stratification is helpful to define inclusion criteria for trials, enables comparison and pooling of trial results and can be used for epidemiological research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim was to develop extent, severity and impact strata for the SA\u2010VES based on validated anchor\u2010based questions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 315 patients with vitiligo (non\u2010segmental; age\u00a0\u2265\u00a016) recruited at the Ghent University Hospital (Belgium) completed a questionnaire that was conducted in cooperation with the Dutch Society for vitiligo patients to ensure content validity. First three anchor questions included in the questionnaire [Patient Global Assessment (PtGA) for vitiligo extent, severity and impact] were assessed for content validity, construct validity and intrarater reliability. Subsequently, the PtGAs were used to stratify the SA\u2010VES based on ROC analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For all PtGAs (PtGA extent, PtGA severity, PtGA impact), at least 75% of hypotheses evaluated for construct validity were confirmed. Intrarater reliability of all PtGAs was good to excellent (ICCs PtGA extent: 0.623; PtGA severity: 0.828; PtGA impact: 0.851). The optimal cut\u2010off values of the SA\u2010VES between the three global categories (mild\/limited \u2013 moderate \u2013 severe\/extensive) were 1.05% and 6.45% based on PtGA extent, 2.07% and 4.8% based on PtGA severity and 2% and 3.35% based on PtGA impact.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides the first guide for the interpretation of the numerical output obtained by the SA\u2010VES (vitiligo extent) and enables the translation into a global vitiligo grading for extent, severity and impact. As patients\u2019 interpretation of vitiligo extent, severity and impact may vary amongst patients worldwide, future international studies will be required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.16562","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T07:42:51Z","timestamp":1590478971000},"page":"216-221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Validation of a Patient Global Assessment for extent, severity and impact to define the severity strata for the Self Assessment Vitiligo Extent Score (SA\u2010VES)"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3249-8195","authenticated-orcid":false,"given":"N.","family":"van Geel","sequence":"first","affiliation":[{"name":"Department of Dermatology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6031-2116","authenticated-orcid":false,"given":"S.E.","family":"Uitentuis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute for Pigment Disorders and Infection &amp; Immunity Institute Amsterdam UMC Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zuidgeest","sequence":"additional","affiliation":[{"name":"Dutch Society for Vitiligo Patients (Vitiligo.NL) The Hague The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wolkerstorfer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute for Pigment Disorders and Infection &amp; Immunity Institute Amsterdam UMC Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.W.","family":"Bekkenk","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute for Pigment Disorders and Infection &amp; Immunity Institute Amsterdam UMC Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Moock","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Science Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Van Goethem","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Science Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Verlaeckt","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Science Ghent University Ghent 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