{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:55:13Z","timestamp":1791078913874,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Retinoids have long been used in the treatment of cutaneous T\u2010cell lymphomas. However, data on acitretin use for mycosis fungoides (MF) are very limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate treatment outcomes of acitretin in patients with MF attending three academic referral centres in different regions of Greece.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on effectiveness, safety and drug survival of acitretin as monotherapy or as adjuvant regimen were collected in a multicentre, register\u2010based, retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 128 patients (64.8% male; mean age at MF diagnosis 59.7\u00a0years) were included. Folliculotropic MF was present in 24 (18.8%) cases. Most patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0118; 92.2%) had early\u2010stage disease (\u2264IIA) at acitretin initiation. In all, 28 (21.9%) patients received acitretin monotherapy, while 100 (78.1%) subjects on acitretin concomitantly received phototherapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a065; 50.8%) or topical steroids (<jats:italic>n<\/jats:italic>\u00a0=\u00a027; 21.1%). Acitretin was given as a first\u2010line agent in 73 (57%) cases. A 77.3% overall response rate was noted: 44.5% and 32.8% for complete and partial responses, respectively. Acitretin was more effective as first\u2010line than as a subsequent agent (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.008). A trend towards better response was observed in the combination arm compared to patients receiving acitretin alone (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.056). Median time to best response was 6.9\u00a0months (IQR 4.4\u20139.4); median duration of response was 23.7\u00a0months (IQR 11.9\u201335.4). Overall, the mean length of all treatment patterns was 569\u00a0days (SD 718.8). Therapy was discontinued in 5 (3.9%) cases due to drug intolerance. Adverse effects were recorded in 62 (48.4%) cases with dyslipidaemia (<jats:italic>n<\/jats:italic>\u00a0=\u00a031; 24.2%), xerosis (<jats:italic>n<\/jats:italic>\u00a0=\u00a024; 18.6%) and hair loss (<jats:italic>n<\/jats:italic>\u00a0=\u00a010; 7.8%) being the most commonly recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acitretin, either alone or as adjuvant, showed a stable long\u2010term effectiveness in this cohort, especially when used in the first\u2010line setting. This RAR\u2010selective agonist may serve as an attractive option for treatment of MF and should be further evaluated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16567","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T10:17:08Z","timestamp":1588587428000},"page":"2534-2540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Monotherapy and combination therapy with acitretin for mycosis fungoides: results of a retrospective, multicentre study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9340-9152","authenticated-orcid":false,"given":"V.","family":"Nikolaou","sequence":"first","affiliation":[{"name":"1st Department of Dermatology\u2010Venereology Faculty of Medicine National and Kapodistrian University of Athens \u201cA. 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Sygros\u201d Hospital for Venereal and Skin Diseases Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Chlouverakis","sequence":"additional","affiliation":[{"name":"Laboratory of Biostatistics School of Medicine University of Crete Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kavvalou","sequence":"additional","affiliation":[{"name":"Department of Dermatology\u2010Venereology University General Hospital of Heraklion Heraklion\/Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Koletsa","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology Faculty of Medicine Aristotle University Papageorgiou University Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Economidi","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology\u2010Venereology Faculty of Medicine National and Kapodistrian University of Athens \u201cA. 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