{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:53:12Z","timestamp":1771462392440,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011110","name":"UCB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Certolizumab, a pegylated tumour necrosis factor\u2010\u03b1 inhibitor, reduced disease activity in randomized trials of patients with psoriasis and psoriatic arthritis. Real\u2010life data are missing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To confirm the effectiveness and safety of certolizumab in patients with psoriasis and psoriatic arthritis in routine clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study involving 11 Italian sites, patients with psoriasis and psoriatic arthritis received subcutaneous certolizumab (400\u00a0mg loading dose at 0, 2 and 4\u00a0weeks, followed by 200\u00a0mg every 2\u00a0weeks) for up to 52\u00a0weeks. Primary outcomes included mean change from baseline in Psoriasis Area and Severity Index (PASI) and modified Nail Psoriasis Severity Index (mNAPSI) scores, and the proportion of patients achieving a 75%, 90% or 100% reduction in PASI score. Other endpoints included Disease Activity Score computed on 44 joints correlated with the erythrocyte sedimentation rate during the first hour (DAS44\u2010ESR), Tender Joint Count (TJC), Swollen Joint Count (SJC), pain [visual analogue scale (VAS) score], inflammatory markers and quality of life (QOL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the study were enrolled 153 patients (mean age: 55\u00a0years). Certolizumab reduced the mean PASI score from baseline by 4.45, 6.30 and 7.58 at weeks 12, 24 and 52, respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 for all). At weeks 24 and 52, 69.6% and 83.3% of patients had a PASI score \u22643. DAS44\u2010ESR, TJC, SJC and mNAPSI scores, and pain VAS were also all significantly improved from baseline at each time point. C\u2010reactive protein levels decreased during treatment, being significant at week 24. On multivariate analysis, psoriasis duration, baseline PASI, mNAPSI and pain VAS scores were found to be predictive of the improvement in PASI score at week 12.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Certolizumab displayed also in the real\u2010life encouraging results in both psoriasis and psoriatic arthritis patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16606","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T12:44:20Z","timestamp":1589373860000},"page":"2839-2845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Certolizumab for the treatment of psoriasis and psoriatic arthritis: a real\u2010world multicentre Italian study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9504-5882","authenticated-orcid":false,"given":"A.","family":"Dattola","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Rome \u201cTor Vergata\u201d Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5485-0172","authenticated-orcid":false,"given":"A.","family":"Balato","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1803-2046","authenticated-orcid":false,"given":"M.","family":"Megna","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1777-9001","authenticated-orcid":false,"given":"P.","family":"Gisondi","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8548-0493","authenticated-orcid":false,"given":"G.","family":"Girolomoni","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"De Simone","sequence":"additional","affiliation":[{"name":"Institute of Dermatology Catholic University Rome Italy"},{"name":"Dermatology Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8837-9232","authenticated-orcid":false,"given":"G.","family":"Caldarola","sequence":"additional","affiliation":[{"name":"Institute of Dermatology Catholic University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Cama","sequence":"additional","affiliation":[{"name":"Dermatology Unit Department of Medicine University of Padua Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Piaserico","sequence":"additional","affiliation":[{"name":"Dermatology Unit Department of Medicine University of Padua Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7249-2556","authenticated-orcid":false,"given":"M.C.","family":"Fargnoli","sequence":"additional","affiliation":[{"name":"Department Dermatology Department of Biotechnological and Applied Clinical Sciences University of L'Aquila L'Aquila Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Fidanza","sequence":"additional","affiliation":[{"name":"Department Dermatology San Salvatore Hospital University of L'Aquila L'Aquila Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Parodi","sequence":"additional","affiliation":[{"name":"Section of Dermatology DISSAL San Martino\u2010IST Polyclinic Hospital University of Genoa Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4381-6718","authenticated-orcid":false,"given":"M.","family":"Burlando","sequence":"additional","affiliation":[{"name":"Section of Dermatology DISSAL San Martino\u2010IST Polyclinic Hospital University of Genoa Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Offidani","sequence":"additional","affiliation":[{"name":"Dermatology Unit Department of Clinical and Molecular Sciences Polytechnic Marche University Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Diotallevi","sequence":"additional","affiliation":[{"name":"Dermatology Unit Department of Clinical and Molecular Sciences Polytechnic Marche University Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Potenza","sequence":"additional","affiliation":[{"name":"Department of Medical\u2010Surgical Sciences and Bio\u2010Technologies Sapienza University of Rome, Polo Pontino Terracina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Conti","sequence":"additional","affiliation":[{"name":"Dermatology Unit Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine University of Modena and Reggio Emilia Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Chiricozzi","sequence":"additional","affiliation":[{"name":"Institute of Dermatology Catholic University Rome Italy"},{"name":"Dermatology Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy"},{"name":"Dermatology Unit Department of Clinical and Experimental Medicine University of Pisa Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Campione","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Rome \u201cTor Vergata\u201d Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Rome \u201cTor Vergata\u201d Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61909-7"},{"key":"e_1_2_8_3_1","first-page":"278","article-title":"Diagnosis and management of psoriasis","volume":"63","author":"Kim WB","year":"2017","journal-title":"Can Fam Physician"},{"key":"e_1_2_8_4_1","first-page":"3140682","article-title":"Psoriasis and respiratory comorbidities: the added value of fraction of exhaled nitric oxide as a new method to detect, evaluate, and monitor psoriatic systemic involvement and therapeutic efficacy","volume":"23","author":"Santus P","year":"2018","journal-title":"Biomed Res Int"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122514"},{"key":"e_1_2_8_6_1","first-page":"165","article-title":"New insights into the pathogenesis of cutaneous autoimmune disorders","volume":"26","author":"Chiricozzi A","year":"2012","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.11.057"},{"key":"e_1_2_8_8_1","first-page":"5","article-title":"Emerging therapies in psoriasis: a systematic review","volume":"101","author":"Lee EB","year":"2018","journal-title":"Cutis"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112297"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208337"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2017.1283401"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010228"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.2.2.11271"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203696"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.04.012"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.04.013"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10941.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1605143"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-017-0208-z"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2018.02.010"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13354"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14114"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20577"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365390"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15258"},{"key":"e_1_2_8_26_1","doi-asserted-by":"crossref","first-page":"e000582","DOI":"10.1136\/rmdopen-2017-000582","article-title":"4\u2010year results from the RAPID\u2010PsA phase 3 randomised placebo\u2010controlled trial of certolizumab pegol in psoriatic arthritis","volume":"4","author":"Heijde D","year":"2018","journal-title":"RMD Open"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1448788"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2015-000119"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.16606","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16606","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.16606","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T19:22:59Z","timestamp":1693423379000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.16606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,26]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/jdv.16606"],"URL":"https:\/\/doi.org\/10.1111\/jdv.16606","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,26]]},"assertion":[{"value":"2020-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}