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Photoageing, photocarcinogenesis and pigmentary changes are well\u2010established consequences of chronic exposure of the skin to solar radiation. Exposure to traffic\u2010related air pollution contributes to skin ageing. Particulate matter and nitrogen dioxide cause skin pigmentation\/lentigines, while ozone causes wrinkles and has an impact on atopic eczema. Human skin is a major target of hormones, and they exhibit a wide range of biological activities on the skin. Hormones decline with advancing age influencing skin ageing. Nutrition has an impact on numerous biochemical processes, including oxidation, inflammation and glycation, which may result in clinical effects, including modification of the course of skin ageing and photoageing. Stress and lack of sleep are known to contribute to a pro\u2010inflammatory state, which, in turn, affects the integrity of extracellular matrix proteins, in particular collagen. Hormone dysregulation, malnutrition and stress may contribute to inflammatory skin disorders, such as atopic dermatitis, psoriasis, acne and rosacea.<\/jats:p>","DOI":"10.1111\/jdv.16614","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T04:15:03Z","timestamp":1594959303000},"page":"4-25","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":184,"title":["Clinical and biological impact of the exposome on the skin"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-6570","authenticated-orcid":false,"given":"T.","family":"Passeron","sequence":"first","affiliation":[{"name":"C\u00f4te d'Azur University Department of Dermatology University Hospital Centre Nice Nice France"},{"name":"C\u00f4te d\u2019Azur University, INSERM U1065, C3M Nice 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