{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:58:07Z","timestamp":1790816287942,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Frontal fibrosing alopecia (FFA) is a lymphocytic scarring alopecia whose worldwide incidence is rising. Environmental triggers combined with genetic predisposition represent one of the current hypotheses in FFA aetiology. Familial clusters are opportunities to investigate the genetic basis of diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Assess human leucocyte antigen (HLA) genetic variability in a Brazilian sample of a large familial cluster (six sisters and one daughter) with FFA, unnafected familiar members and sporadic cases of FFA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We addressed the <jats:italic>HLA\u2010A<\/jats:italic>, <jats:italic>HLA\u2010B<\/jats:italic>, <jats:italic>HLA\u2010C<\/jats:italic>, <jats:italic>HLA\u2010G<\/jats:italic> and <jats:italic>HLA\u2010E<\/jats:italic> genetic variability in this family and in seven sporadic FFA cases, comparing allele frequencies with those reported for the S\u00e3o Paulo State from Brazil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two susceptibility haplotypes, C*17:01:01:02\/B*42:01:01:01 and C*07:02:01:03\/B*07:02:01:01, were identified among familial cases and also in sporadic cases. The first haplotype is rare among Brazilians, and it was not previously reported as being associated with FFA. Both alleles were found in some different unaffected familiars, what emphasizes the role of environmental triggers in disease development. <jats:italic>HLA\u2010A<\/jats:italic>, <jats:italic>HLA\u2010G<\/jats:italic> and <jats:italic>HLA\u2010E<\/jats:italic> genes were not associated to familiar nor FFA sporadic cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The identification of susceptibility haplotypes in FFA reinforces the genetic predisposition to the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16629","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T22:55:40Z","timestamp":1589842540000},"page":"2409-2413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A large familial cluster and sporadic cases of frontal fibrosing alopecia in Brazil reinforce known human leucocyte antigen (HLA) associations and indicate new HLA susceptibility haplotypes"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1561-414X","authenticated-orcid":false,"given":"P.M.","family":"Ramos","sequence":"first","affiliation":[{"name":"Departamento de Dermatologia e Radioterapia Universidade Estadual Paulista - UNESP Botucatu SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5867-1454","authenticated-orcid":false,"given":"L.E.F.M.","family":"Garbers","sequence":"additional","affiliation":[{"name":"Departamento de Dermatologia e Radioterapia Universidade Estadual Paulista - UNESP Botucatu SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5511-8426","authenticated-orcid":false,"given":"N.S.B.","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Universidade Estadual Paulista - UNESP Botucatu SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8010-4496","authenticated-orcid":false,"given":"C.F.B.","family":"Castro","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Universidade Estadual Paulista - UNESP Botucatu SP Brazil"},{"name":"Centro Universit\u00e1rio Sudoeste Paulista Avar\u00e9 SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5090-7127","authenticated-orcid":false,"given":"H.S.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00e9tica Molecular e Bioinform\u00e1tica Unidade de Pesquisa Experimental (Unipex) Universidade Estadual Paulista - UNESP Botucatu SP Brazil"},{"name":"Instituto de Bioci\u00eancias Universidade Estadual Paulista - UNESP Botucatu SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6853-1559","authenticated-orcid":false,"given":"A.S.","family":"Souza","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00e9tica Molecular e Bioinform\u00e1tica Unidade de Pesquisa Experimental (Unipex) Universidade Estadual Paulista - UNESP Botucatu SP Brazil"},{"name":"Instituto de Bioci\u00eancias Universidade Estadual Paulista - UNESP Botucatu SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2142-7196","authenticated-orcid":false,"given":"E.C.","family":"Castelli","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Universidade Estadual Paulista - UNESP Botucatu SP Brazil"},{"name":"Laborat\u00f3rio de Gen\u00e9tica Molecular e Bioinform\u00e1tica Unidade de Pesquisa Experimental (Unipex) Universidade Estadual Paulista - UNESP Botucatu SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2596-9294","authenticated-orcid":false,"given":"H.A.","family":"Miot","sequence":"additional","affiliation":[{"name":"Departamento de Dermatologia e Radioterapia Universidade Estadual Paulista - UNESP Botucatu SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489793"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12945"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4233"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15735"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13071"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09117-w"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12985"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2019.02.009"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10709-016-9894-1"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.20474"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2018.06.010"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12352"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34961"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-015-0149-5"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng934"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08818.x"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1087-0024.2003.00807.x"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2013.0197"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07209-7"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-018-1861-5"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.16629","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16629","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.16629","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T11:50:07Z","timestamp":1693828207000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.16629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,26]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/jdv.16629"],"URL":"https:\/\/doi.org\/10.1111\/jdv.16629","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,26]]},"assertion":[{"value":"2020-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}