{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T19:23:35Z","timestamp":1768677815671,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Psoriatic disease is associated with considerable impairment of quality of life (QoL). The PROSE study (NCT02752776) investigated the impact of secukinumab treatment on patient\u2010reported outcomes (PRO) in patients with moderate to severe psoriasis stratified by their treatment history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PROSE was a prospective, non\u2010randomised, multicentre study. Patients were categorized at baseline according to treatment history as na\u00efve [na\u00efve to any systemic therapy (<jats:italic>N<\/jats:italic>\u00a0=\u00a0663)], conventional systemic [previously exposed to \u22651 conventional systemic (CS) therapy (<jats:italic>N<\/jats:italic>\u00a0=\u00a0673)] and biologics [previously exposed to \u22651 biologic therapy (<jats:italic>N<\/jats:italic>\u00a0=\u00a0324)]. QoL PROs, efficacy and safety of secukinumab 300\u00a0mg were assessed for a period of 52\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The primary objective was met with 70.8% patients achieving a Dermatology Life Quality Index (DLQI) 0\/1 response at Week 16 (na\u03cave, 74.7%; CS, 71.3%; biologic, 61.7%), with effects sustained up to Week 52. Mean Family DLQI (FDLQI) score decreased from 11.5 at baseline (na\u03cave, 11.3; CS, 11.4; biologic, 12.1) to 2.5 at Week\u00a016 (na\u03cave, 2.5; CS, 2.3; biologic: 3.5). Substantial improvements in EuroQoL 5\u2010Dimension Health Questionnaire, Numeric Rating Scale for pain, itching and scaling, Health Assessment Questionnaire\u2010Disability Index, Treatment Satisfaction Questionnaire for Medication, and Patient Benefit Index were also observed at Week\u00a016. The QoL gains were associated with substantial improvements in Psoriasis Area and Severity Index and Investigator Global Assessment mod 2011 0\/1 response. No meaningful difference was observed in the efficacy or QoL improvements across patient subpopulations. All QoL and efficacy parameter improvements were sustained up to Week 52. Secukinumab treatment was well\u2010tolerated, and no new safety signals were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Secukinumab treatment resulted in complete normalization of QoL in a substantial proportion of psoriasis patients, and their families, regardless of their prior treatment history.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16632","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T12:17:25Z","timestamp":1589890645000},"page":"431-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Secukinumab treatment leads to normalization of quality of life and disease symptoms in psoriasis patients with or without prior systemic psoriasis therapy: the PROSE study results"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4026-8728","authenticated-orcid":false,"given":"M.","family":"Augustin","sequence":"first","affiliation":[{"name":"Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Centre Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0676-1260","authenticated-orcid":false,"given":"E.","family":"Dauden","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de la Princesa Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9539-0712","authenticated-orcid":false,"given":"U.","family":"Mrowietz","sequence":"additional","affiliation":[{"name":"Psoriasis\u2010Center Department of Dermatology University Medical Center Schleswig\u2010Holstein, Campus Kiel Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8171-6542","authenticated-orcid":false,"given":"M.P.","family":"Konstantinou","sequence":"additional","affiliation":[{"name":"Department of Dermatology Paul Sabatier University Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gerdes","sequence":"additional","affiliation":[{"name":"Psoriasis\u2010Center Department of Dermatology University Medical Center Schleswig\u2010Holstein, Campus Kiel Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kingo","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Tartu University Hospital Department of Dermatology, University of Tartu Tartu Estonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0766-6342","authenticated-orcid":false,"given":"J.C.","family":"Szepietowski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Wroclaw Medical University Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.L.","family":"Perrot","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Allergology Jacques Lisfranc University Saint\u2010Etienne France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cuccia","sequence":"additional","affiliation":[{"name":"Unit of Dermatology San Donato Hospital Arezzo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rissler","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gathmann","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Sieder","sequence":"additional","affiliation":[{"name":"Novartis Pharma GmbH Nuernberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Orsenigo","sequence":"additional","affiliation":[{"name":"Novartis Farma S.p.A Origgio Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Jagiello","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Bachhuber","sequence":"additional","affiliation":[{"name":"Novartis Pharma GmbH Nuernberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15065"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4103\/ijp.IJP_166_16","article-title":"A study of the use of drugs in patients suffering from psoriasis and their impact on quality of life","volume":"49","author":"Karamata VV","year":"2017","journal-title":"Indian J Pharmacol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2018.1401468"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052935"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12355"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2600"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-018-1832-x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2017.71.341-346"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14254"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-2-12"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000209234"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02593.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07617.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14288"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12110"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314258"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12359"},{"issue":"6","key":"e_1_2_6_19_1","first-page":"S12","article-title":"Secukinumab in the treatment of palmoplantar, nail, scalp, and pustular psoriasis","volume":"9","author":"Armstrong AW","year":"2016","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12751"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)61134-5"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(90)90421-9"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0764"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12645"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2013.1988"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737167.2014.914437"},{"key":"e_1_2_6_28_1","first-page":"167","article-title":"The Stanford Health Assessment Questionnaire: a review of its history, issues, progress, and documentation","volume":"30","author":"Bruce B","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_6_29_1","first-page":"789","article-title":"The dimensions of health outcomes: the health assessment questionnaire, disability and pain scales","volume":"9","author":"Fries JF","year":"1982","journal-title":"J Rheumatol"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.04.045"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14878"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.08.008"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18361"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15962"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16400"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.16632","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16632","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.16632","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:42:29Z","timestamp":1722904949000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.16632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/jdv.16632"],"URL":"https:\/\/doi.org\/10.1111\/jdv.16632","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"2020-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}