{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:01:29Z","timestamp":1788368489385,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Novel picosecond lasers using a diffractive optical element (P\u2010DOE) have been available for skin resurfacing with distinct mechanisms. However, there are limited data directly comparing P\u2010DOE and conventional fractional lasers for the treatment of atrophic acne scarring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to compare the efficacy and safety of a 1064\u2010nm neodymium\u2010doped yttrium aluminium garnet P\u2010DOE and a non\u2010ablative fractional laser (NAFL) in the treatment of acne scarring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, randomized, split\u2010face, controlled trial was performed. One randomly assigned half\u2010side of each patient\u2019s face (<jats:italic>n<\/jats:italic>\u00a0=\u00a025) was treated with four consecutive sessions of P\u2010DOE at 3\u2010week intervals and the other side with NAFL, with subsequent follow\u2010up for 8\u00a0weeks after the final sessions. The efficacy and safety of the two lasers were determined by the Echelle d'Evaluation Clinique des Cicatrices d'acn\u00e9 (Scale of Clinical Evaluation of Acne Scars; ECCA) grading scale, Investigator\u2019s Global Assessment (IGA) score and patients\u2019 reports at the final visit. Histologic analysis was also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The P\u2010DOE\u2010treated side achieved a significantly better improvement in acne appearance (ECCA per cent reduction: 55% vs. 42%) with less severe pain (4.3 vs. 5.6) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The IGA score and subjective satisfaction were consistent with ECCA score results. Occurrences of treatment\u2010related side\u2010effects were also lower in the group treated with P\u2010DOE (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Histologic analysis revealed elongation and increased density of neocollagen fibres, elastic fibres and mucin throughout the dermis from both sides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with NAFL, P\u2010DOE afforded better clinical outcomes and fewer side\u2010effects in the treatment of acne scarring in Asian patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16643","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T12:55:59Z","timestamp":1593521759000},"page":"2907-2913","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Comparison of a 1064\u2010nm neodymium\u2010doped yttrium aluminum garnet picosecond laser using a diffractive optical element vs. a nonablative 1550\u2010nm erbium\u2010glass laser for the treatment of facial acne scarring in Asian patients: a 17\u2010week prospective, randomized, split\u2010face, controlled trial"],"prefix":"10.1111","volume":"34","author":[{"given":"H.H.","family":"Kwon","sequence":"first","affiliation":[{"name":"Oaro Dermatology Clinic Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.H.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.J.","family":"Cho","sequence":"additional","affiliation":[{"name":"Oaro Dermatology Clinic Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Pathology Dongtan Sacred Heart Hospital Hallym University College of Medicine Hwaseong Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ilsan Paik Hospital Inje University College of Medicine Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dongtan Sacred Heart Hospital Hallym University College of Medicine Hwaseong Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.Y.","family":"Jung","sequence":"additional","affiliation":[{"name":"Oaro Dermatology Clinic Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8890-8678","authenticated-orcid":false,"given":"G.\u2010H.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dongtan Sacred Heart Hospital Hallym University College of Medicine Hwaseong 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