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Oesophagus, following the oropharyngeal mucosa, is the most common GI segment affected by primary skin diseases, especially by eosinophilic oesophagitis, lichen planus and autoimmune bullous dermatoses like pemphigus vulgaris, mucosal membrane pemphigoid and epidermolysis bullosa acquisita. Eosinophilic oesophagitis is an emerging chronic atopic disease with oesophageal dysfunction as the typical presentation, and oesophageal narrowing, rings and stricture as late complications. Oesophageal lichen planus mainly involves the proximal to mid\u2010oesophagus in elderly aged women with long\u2010term oral mucosal lesions. In acute attack of pemphigus vulgaris, oesophageal involvement is not uncommon but often neglected and may cause sloughing oesophagitis (oesophagitis dissecans superficialis) with acute GI bleeding in rare cases. GI manifestation of hereditary bradykininergic angio\u2010oedema with colicky acute abdomen mostly affects small intestine, usually in the absence of pruritus or urticaria, and is more severe and long\u2010lasting than the acquired histaminergic form. Strong evidence supports association between inflammatory bowel disease, especially Crohn disease, and hidradenitis suppurativa\/acne inversa. Patients with vitiligo need surveillance of autoimmune liver disease, autoimmune atrophic gastritis or coeliac disease when corresponding symptoms become suspect. Melanoma is the most common primary tumour metastatic to the GI tract, with small intestine predominantly targeted. Gastrointestinal involvement is not uncommon in disseminated mycosis fungoides. Extramammary Paget\u2019s disease is an intraepidermal adenocarcinoma of controversial origin, and a high association between the anogenital occurrence and colorectal adenocarcinoma has been reported. As GI tract is the largest organ system with multidimensional functions, dermatologists in daily practice should be aware of the gastrointestinal morbidities related to primary skin diseases for an early diagnosis and treatment.<\/jats:p>","DOI":"10.1111\/jdv.16676","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T21:40:45Z","timestamp":1590529245000},"page":"2766-2774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Gastrointestinal involvement of primary skin diseases"],"prefix":"10.1111","volume":"34","author":[{"given":"C.\u2010Y.","family":"Lu","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan"},{"name":"Department of Internal Medicine Faculty of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010S.","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kaohsiung Municipal Siaogang Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.\u2010C.","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ezmerli","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine in Rabigh Kingdom of Saudi Arabia King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010H.","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Internal Medicine Kaohsiung Municipal Siaogang Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7720-0228","authenticated-orcid":false,"given":"W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Research &amp; Development Kaohsiung Municipal Siaogang Hospital Kaohsiung Taiwan"},{"name":"Department of Dermatology and Allergy Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,25]]},"reference":[{"key":"e_1_2_15_2_1","volume-title":"Embryology, Gastrointestinal. 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