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Illustrative of this is the resistance to topical erythromycin and clindamycin which continues to be a problem worldwide, while resistance to systemic treatment with tetracyclines has remained low during the past decade. The resistance for the newer macrolides like azithromycin and clarithromycin has been increasing. The results of antibiotic resistance may include treatment failure of acne, disturbance of skin microbiota, induction of opportunistic pathogens locally and systemically, and dissemination of resistant strains to both healthcare personnel and the general population. The ensuing complications, such as aggravated opportunistic infections caused by <jats:italic>Propionibacterium acnes<\/jats:italic> and the emergence of multiresistant superbugs, have not yet been confirmed.<\/jats:p>","DOI":"10.1111\/jdv.16686","type":"journal-article","created":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T19:21:05Z","timestamp":1590952865000},"page":"73-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Antibiotic resistance in acne: changes, consequences and concerns"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4333-8274","authenticated-orcid":false,"given":"A.S.","family":"Karadag","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology School of Medicine Istanbul Medeniyet University, Goztepe Research and Training Hospital Istanbul 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