{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:50:40Z","timestamp":1787064640143,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"S6","license":[{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pierre Fabre laboratory"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In patients with psoriasis, the non\u2010lesional skin also presents abnormalities, requiring emollient application on the whole body.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the tolerance of a new emollient balm containing celastrol, an active ingredient with anti\u2010Th17 immunomodulatory properties used alone or in association with topical or systemic drug treatments or phototherapy, and its efficacy when used alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults with body plaque psoriasis applied the product over the whole body once a day for 4\u00a0weeks (balm used alone in 41 patients and with ongoing treatment in 50 patients). At D1, D8 (\u2018balm alone\u2019 study) or D15 (\u2018balm in association\u2019 study) and D29, the dermatologist rated physical and functional signs and assessed pruritus and body global lesion score (evaluating erythema, induration\/thickness, scaling and dryness) in the \u2018balm alone\u2019 study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No reaction related to the product was reported, and the tolerance was deemed excellent. In the \u2018balm alone\u2019 study, mean pruritus intensity score significantly decreased at D8 (\u221239%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and D29 (\u221260%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) compared with D1, together with the body global lesion score (\u221224% at D8 and \u221226% at D29,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). In parallel, quality of life improved, as evidenced by a patient\u2010reported outcome questionnaire. Cosmetic acceptability was good.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This new emollient balm was very well tolerated by patients with body plaque psoriasis either alone or in association with drug treatment or phototherapy, which is important to ensure long\u2010term compliance. Daily application during one month improved pruritus, physical signs and quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.16691","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T05:45:28Z","timestamp":1597211128000},"page":"10-16","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Tolerance and efficacy of a new celastrol\u2010containing balm as adjunct care in psoriasis"],"prefix":"10.1111","volume":"34","author":[{"given":"M.D.","family":"Thouvenin","sequence":"first","affiliation":[{"name":"Clinical Skin Research and Development Center Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Dalmon","sequence":"additional","affiliation":[{"name":"Clinical Skin Research and Development Center Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Theunis","sequence":"additional","affiliation":[{"name":"Clinical Skin Research and Development Center Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lauze","sequence":"additional","affiliation":[{"name":"Clinical Skin Research and Development Center Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Coubetergues","sequence":"additional","affiliation":[{"name":"Clinical Skin Research and Development Center Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Mengeaud","sequence":"additional","affiliation":[{"name":"Medical Department Laboratoires dermatologiques Ducray Les Cauquillous France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Calvet","sequence":"additional","affiliation":[{"name":"Clinical Skin Research and Development Center Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-7-62"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.768"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03829.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12476"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.173"},{"key":"e_1_2_7_7_1","first-page":"794","article-title":"Reproducible novel transcriptional differences between psoriatic lesional and non\u2010lesional skin show increased inflammation and metabolism","volume":"14","author":"Aires DJ","year":"2015","journal-title":"J drugs dermatol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2014.2294"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14891"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-015-0068-3"},{"key":"e_1_2_7_11_1","unstructured":"National Clinical Guideline C.National Institute for Health and Clinical Excellence: Guidance. Psoriasis: Assessment and Management of Psoriasis. London. Royal College of Physicians (UK) Copyright (c) National Clinical Guideline Centre 2012."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.12.032"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16475"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12555"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000083509"},{"key":"e_1_2_7_16_1","unstructured":"NguyenT CousyA StewardN.Method for producing celastrol and pentacyclic triterpene derivatives. 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