{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:52:40Z","timestamp":1791924760960,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dupilumab is approved for use in moderate\u2010to\u2010severe atopic dermatitis (AD) and as an add\u2010on maintenance treatment in patients suffering from severe asthma with type 2 inflammation. Ocular adverse events (OAEs) have been reported with dupilumab almost exclusively in patients treated for AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objectives of this study were to describe the incidence and nature of dupilumab\u2010induced OAEs and to assess the potential predisposing factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>We conducted a prospective, single\u2010centre, real\u2010life study in adult AD patients treated with dupilumab, who were systematically examined by an ophthalmologist before and during treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six patients were included prospectively with a median age of 41.1\u00a0years and a median initial SCOring Atopic Dermatitis of 46.0 (IQR: 34.5\u201355.5). OAEs concerned 34.8% of patients and were mostly of mild to moderate severity. Two patients had to discontinue treatment due to OAE. The majority of patients developed or aggravated dry eye disease, with superficial punctate keratitis (SPK). Six patients developed conjunctivitis. Dupilumab\u2010induced OAEs were associated with the following pre\u2010existing parameters: dry eye disease with SPK (Odds ratio (OR); 6.3 [95% confidence interval (CI): 1.3\u201331.6]), eyelid eczema (OR: 8.7 [95%CI: 1.8\u201340.6]), history of food allergy (OR 3.8 (95% CI: 1.002\u201314,070) and IgE serum level&gt;\u00a01000\u00a0kU\/L (OR:10.6 [CI 95%: 1.2\u201391.3]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Atopic dermatitis patients with eyelid eczema or dry eye disease symptoms may be referred to an ophthalmologist before starting dupilumab to consider initiating preventive eye hydration measures. Further multicentric and translational studies are warranted to better explain OAEs pathophysiology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16724","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T23:59:13Z","timestamp":1591833553000},"page":"172-179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Incidence and risk factors for dupilumab associated ocular adverse events: a real\u2010life prospective study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6101-843X","authenticated-orcid":false,"given":"A.T.","family":"Touhouche","sequence":"first","affiliation":[{"name":"Dermatology and Allergology Department Toulouse University Hospital and Inserm 1056 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cassagne","sequence":"additional","affiliation":[{"name":"Ophtalmology Department 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