{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:12:30Z","timestamp":1791389550705,"version":"4.3.3"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Comorbidities are associated with higher health care costs, complex management, and poorer health outcomes. Identification and treatment of comorbid conditions in paediatric alopecia areata (AA) patients could provide an opportunity to improve health outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the prevalence of comorbidities among paediatric patients with AA using a large de\u2010identified aggregated patient database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a cross\u2010sectional study using aggregated health record data through April 1, 2019. Patients \u226418\u00a0years of age, with alopecia areata (<jats:italic>n<\/jats:italic>\u00a0=\u00a03510) and without alopecia areata (<jats:italic>n<\/jats:italic>\u00a0=\u00a08\u00a0310\u00a0710) were identified. The primary outcome was the prevalence of comorbidities among AA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 8\u00a0314\u00a0220 paediatric patients, 3510 (1570 males and 1940 females) had a diagnosis of alopecia areata. The most common comorbidities included atopic dermatitis (17.4% vs. 2.2% controls, OR 9.2, 95% CI 8.55\u201310.18, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), anaemia (7.7% vs. 2.4% controls, OR 3.4, 95% CI 3.06\u20133.92, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), obesity (5.7% vs. 1.1% controls, OR 5.6, 95% CI 4.76\u20136.34, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), vitamin D deficiency (5.1% vs. 0.4% controls, OR 14.7, 95% CI 13.5\u201318.1, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), hypothyroidism (2.6% vs. 0.2% controls, OR 12, 95% CI 10.73\u201315.9, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), vitiligo (1.4% vs. 0.04% controls, OR 32.2, 95% CI 24.01\u201342.1, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), psoriasis (1.4% vs. 0.07% controls, OR 20.6, 95% CI 15.55\u201327.2, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), hyperlipidemia (1.4% vs. 0.2% controls, OR 5.9, 95% CI 4.4\u20137.7, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and depression (2.6% vs. 0.6% controls, OR 4.8, 95% CI 5.09\u20139.45, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Findings from this study suggest that children with AA are more likely to have certain autoimmune and metabolic disorders than the general paediatric population. Paediatric AA patients display a severe burden of autoimmune and metabolic diseases, thus in daily practice, dermatologists might consider multidisciplinary management in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16727","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T21:01:38Z","timestamp":1591995698000},"page":"2898-2901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Comorbidities in pediatric alopecia areata"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9209-2883","authenticated-orcid":false,"given":"R.Z.","family":"Conic","sequence":"first","affiliation":[{"name":"Department of Surgery University of Maryland Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.L.","family":"Tamashunas","sequence":"additional","affiliation":[{"name":"Department of Dermatology Case Western Reserve University Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2390-6505","authenticated-orcid":false,"given":"G.","family":"Damiani","sequence":"additional","affiliation":[{"name":"Clinical Dermatology IRCCS Istituto Ortopedico Galeazzi Milan Italy"},{"name":"Department of Biomedical, Surgical and Dental Sciences University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Fabbrocini","sequence":"additional","affiliation":[{"name":"Dermatology Division Department of Clinical Medicine and Surgery University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cantelli","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Young Dermatologists Italian Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.F.","family":"Bergfeld","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.1999.99002.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.01.048"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.07.013"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.08.032"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2014.26.6.722"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14648"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13238"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13387"},{"key":"e_1_2_6_10_1","volume-title":"Liberate Your Healthcare Data","author":"The IBM Explorys Platform","year":"2016"},{"key":"e_1_2_6_11_1","volume-title":"The Data Curation Process. 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