{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:26:11Z","timestamp":1790717171694,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hidradenitis suppurativa (HS) has been associated with auto\u2010inflammatory conditions, yet the risk of developing connective tissue disease (CTD), morphoea and systemic vasculitis has not been well\u2010characterized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to evaluate the risk of developing CTD, morphoea and systemic vasculitis in patients with HS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using claims data, we identified patients with HS and used 2\u00a0:\u00a01 risk\u2010set sampling to identify patients without HS. Patients with existing CTD were excluded. Patient follow\u2010up lasted until first occurrence of the following events: the occurrence of outcome (i.e. systemic lupus erythematosus, morphoea, systemic sclerosis, Sjogren\u2019s Syndrome and systemic vasculitis), death, disenrolment or end of data stream. Hazard ratios (HR) of developing CTD, morphoea and systemic vasculitis were computed after 1\u00a0:\u00a01 propensity score (PS) matching.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 2\u00a0:\u00a01 risk\u2010set sampling, we identified 78\u00a0122 HS patients and 156\u00a0247 non\u2010HS comparators. The mean follow\u2010up was 540\u00a0days. After PS matching, HS patients had an increased risk of systemic lupus erythematosus HR\u00a0=\u00a01.63 (1.31\u20132.03) and morphoea HR\u00a0=\u00a02.02 (1.32\u20133.11), compared to non\u2010HS patients. We did not observe an increased risk for systemic sclerosis HR\u00a0=\u00a00.90 (0.59\u20131.44), Sjogren\u2019s Syndrome HR\u00a0=\u00a00.91 (0.73\u20131.14) or systemic vasculitis HR\u00a0=\u00a00.87 (0.64\u20131.20).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this population\u2010based study, we observed an increased risk of developing systemic lupus erythematous and morphoea subsequent to a first\u2010recorded diagnosis of hidradenitis suppurativa.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16728","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T21:02:58Z","timestamp":1591995778000},"page":"195-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Risk of connective tissue disease, morphoea and systemic vasculitis in patients with hidradenitis 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