{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T20:41:22Z","timestamp":1773088882680,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["424536\/2018\u20108"],"award-info":[{"award-number":["424536\/2018\u20108"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pemphigus herpetiformis (PH) is a rare clinical subtype of pemphigus with the presence of urticarial plaques, severe pruritus, rare acantholysis and eosinophilic spongiosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to investigate the influence of IL\u201031 and pro\u2010inflammatory cytokines\/chemokines in the pathogenesis of PH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five patients with PH and three groups: pemphigus foliaceus (PF\u00a0=\u00a014), pemphigus vulgaris (PV\u00a0=\u00a015) and healthy controls (HC\u00a0=\u00a020) were selected for this study. The groups were analysed by immunohistochemistry utilizing IL\u201031, IL\u201031RA, IL\u20104, IL\u201017 and TNF\u2010\u03b1 antibodies. Serum levels of IL\u20104, IL\u201013, TNF, CXCL8, CCL5 and CCL2 were evaluated by cytometric bead array.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analysis of IL\u201031 family of PH patients revealed the following findings: (i) Enhanced <jats:italic>in situ<\/jats:italic> expression of IL\u201031 in PH samples, compared to PF and to PV (epidermis); (ii) Cutaneous IL\u201031RA expression in PH samples was higher than in PF, PV and HC groups (epidermis and dermis); (iii) PF patients that evolved to PH showed significant increased IL\u201031RA epidermal expression during the PH phase. Profile of pro\u2010inflammatory cytokines (IL\u20104, IL\u201017 and TNF\u2010\u03b1) in PH patients\u2019 skin exhibited: (i) Enhanced IL\u20104 expression, when compared to patients with PF (epidermis and dermis) and with PV (epidermis); (ii) Augmented IL\u201017 expression than PF and PV patients (epidermis); (iii) Augmented expression of TNF\u2010\u03b1 when compared to PF at the epidermal level. Evaluation of circulating cytokines and chemokines showed higher levels of CXCL8 and CCL2 in PH sera compared to HC group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IL\u201031 and IL\u201031RA, cytokines related to pruritus, and pro\u2010inflammatory chemokines (CXCL8 and CCL2) seem to exert a role in the pathogenesis of PH. These findings support future studies to clarify the role of IL\u201031 pathway as a potential therapeutic target for patients with PH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16730","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T21:03:13Z","timestamp":1591995793000},"page":"2890-2897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Increased expression of <i>in situ<\/i> IL\u201031RA and circulating CXCL8 and CCL2 in pemphigus herpetiformis suggests participation of the IL\u201031 family in the pathogenesis of the disease"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-5410","authenticated-orcid":false,"given":"K.L.","family":"Morais","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculdade de Medicina FMUSP Universidade de S\u00e3o Paulo S\u00e3o Paulo SP 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