{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T18:05:10Z","timestamp":1766599510655,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1C1B5085905"],"award-info":[{"award-number":["2018R1C1B5085905"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hutchinson\u2019s nail sign (HS) is among the diagnostic criteria for subungual melanoma (SUM). However, there is minimal evidence supporting the overall clinical significance of HS in SUM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify clinicopathological features of SUM according to the extent of HS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study was performed with consecutive SUM patients at a single centre from January 2006 to December 2017. The extent of HS was defined by the number of affected nail folds (range 0\u20134). Comparison groups were organized as follows: patients with HS (affecting \u22651 nail folds) vs. without HS; patients with HS affecting \u22652 nail folds vs. HS affecting &lt;2 nail folds; patients with HS affecting \u22653 nail folds vs. HS affecting &lt;3 nail folds. Clinicopathological characteristics of SUM were compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one SUM patients were included. Forty\u2010six (75.4%) exhibited HS; 22 (47.8%) on a toe and 24 (52.2%) on a finger. In multivariate analysis, nail destruction [hazard ratio (HR), 10.00; 95% confidence interval (CI), 2.61\u201338.30; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.001] was significantly associated with the presence of HS and amputation was significantly associated with HS affecting \u22652 nail folds (HR, 4.75; 95% CI, 1.36\u201316.61; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.015). High T stage (HR, 1.85; 95% CI, 1.20\u20132.85; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.005, Fig. 2) was significantly associated with HS appearing in \u22653 nail folds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Besides its value of detecting SUM, HS provides useful clinical information. The number of nail folds exhibiting HS could be a useful clinical clue for planning therapeutic strategies for SUM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16762","type":"journal-article","created":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T19:46:45Z","timestamp":1592682405000},"page":"380-386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical features of subungual melanoma according to the extent of Hutchinson\u2019s nail sign: a retrospective single\u2010centre study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1452-7896","authenticated-orcid":false,"given":"C.","family":"Sohng","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine, Kyungpook National University Kyungpook National University Hospital Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8856-553X","authenticated-orcid":false,"given":"M.H.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine, Kyungpook National University Kyungpook National University Hospital Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7724-4682","authenticated-orcid":false,"given":"D.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Ulsan University Hospital University of Ulsan College of Medicine Ulsan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6067-7262","authenticated-orcid":false,"given":"K.D.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine, Kyungpook National University Kyungpook National University Hospital Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1706-007X","authenticated-orcid":false,"given":"Y.H.","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine, Kyungpook National University Kyungpook National University Hospital Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5708-1305","authenticated-orcid":false,"given":"W.J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine, Kyungpook National University Kyungpook National University Hospital Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6131-632X","authenticated-orcid":false,"given":"S.J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine, Kyungpook National University Kyungpook National University Hospital Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2999-1018","authenticated-orcid":false,"given":"J.Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine, Kyungpook National University Kyungpook National University Hospital Daegu South 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