{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:55:13Z","timestamp":1782993313670,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Negative life events in childhood can increase the susceptibility to autoimmune and inflammatory diseases. Hidradenitis suppurativa (HS) is a systemic inflammatory disease affecting the apocrine sweat glands, characterized by abscesses, fistulas and inflammatory nodules. It is unknown whether adult HS is associated with traumatic events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between childhood and total lifetime traumatic events and the presence of HS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a matched (1\u00a0:\u00a03) case\u2013control study with 71 HS patients and 213 controls. Patients were matched on age, gender and level of education. Questionnaires on general and demographic information, as well as the Traumatic Experience Checklist and the Hospital Anxiety and Depression Scale, were completed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of traumatic events (OR: 1.20 per trauma, <jats:italic>P<\/jats:italic> value\u00a0&lt;\u00a00.05), and childhood traumatic events (yes vs. no, OR 3.59, <jats:italic>P<\/jats:italic> value\u00a0&lt;\u00a00.05) and the number of childhood traumatic events (OR 1.35 per trauma, <jats:italic>P<\/jats:italic> value\u00a0&lt;\u00a00.05) were correlated with an increased risk of developing HS. Detailed analysis showed that childhood <jats:italic>emotional<\/jats:italic> traumatic events (OR 5.03, <jats:italic>P<\/jats:italic> value\u00a0&lt;\u00a00.05) were significantly associated with the development of HS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Number of lifetime traumatic events and childhood traumatic events are associated with HS. This association is strongest for emotional childhood traumas. The increased prevalence of childhood traumas in HS patients can be one of the underlying mechanisms leading to systemic inflammation in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16828","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T19:03:46Z","timestamp":1595358226000},"page":"2877-2883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hidradenitis suppurativa is associated with childhood and lifetime traumatic events: a case\u2013control study"],"prefix":"10.1111","volume":"34","author":[{"given":"S.","family":"Gielen","sequence":"first","affiliation":[{"name":"Department of Dermatology Vrije Universiteit Brussel (VUB) Universitair Ziekenhuis Brussel (UZB) Jette Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8700-480X","authenticated-orcid":false,"given":"S.R.","family":"Janmohamed","sequence":"additional","affiliation":[{"name":"Department of Dermatology Vrije Universiteit Brussel (VUB) Universitair Ziekenhuis Brussel (UZB) Jette Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Van Laethem","sequence":"additional","affiliation":[{"name":"Department of Dermatology UZ Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Del Marmol","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles (ULB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9266-0342","authenticated-orcid":false,"given":"M.","family":"Suppa","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles (ULB) Brussels Belgium"},{"name":"Department of Dermatology Institut Jules Bordet Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gutermuth","sequence":"additional","affiliation":[{"name":"Department of Dermatology Vrije Universiteit Brussel (VUB) Universitair Ziekenhuis Brussel (UZB) Jette Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Willemsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Vrije Universiteit Brussel (VUB) Universitair Ziekenhuis Brussel (UZB) Jette Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.08.090"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.11.911"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.08.061"},{"key":"e_1_2_6_5_1","first-page":"17","article-title":"Suppurativa: causes, features, and current treatments","volume":"11","author":"Vinkel C","year":"2018","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2450401"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.11337.1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.11.040"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20723"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0866"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.061"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e3181907888"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2013.22"},{"key":"e_1_2_6_14_1","first-page":"415","article-title":"Overview of the impact of child maltreatment on later outcomes and the mediating role of biological systems","volume":"18","author":"Gonzalez A","year":"2013","journal-title":"Paediatr Child Health"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.67"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12217"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chc.2014.01.002"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.10.027"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00087"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.22054"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000356552"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1557"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000072"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0024768"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.00870.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.09.049"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.190009"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.10.042"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031810"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpp.332"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2008.01275.x"},{"key":"e_1_2_6_33_1","unstructured":"Centers for Disease Control and Prevention.Prevalence of individual adverse childhood experiences. World Wide Web site of Centers for Disease Control and Prevention. Data and statistics ACE study. URLhttp:\/\/www.cdc.gov\/nccdphp\/ACE\/prevalence.htm(last accessed: 4 January 2019)."},{"key":"e_1_2_6_34_1","doi-asserted-by":"crossref","first-page":"e0126982","DOI":"10.1371\/journal.pone.0126982","article-title":"Epidemiology of pediatric functional abdominal pain disorders: a meta\u2010analysis","volume":"20","author":"Korterink JJ","year":"2015","journal-title":"PLoS One"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001349"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.0759"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.11.068"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.06.020"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.16828","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16828","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.16828","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T19:23:44Z","timestamp":1693423424000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.16828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,9]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/jdv.16828"],"URL":"https:\/\/doi.org\/10.1111\/jdv.16828","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,9]]},"assertion":[{"value":"2020-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}