{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T21:35:32Z","timestamp":1782423332093,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["2017R1E1A1A01076780"],"award-info":[{"award-number":["2017R1E1A1A01076780"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Systemic effects of long\u2010term narrowband ultraviolet B (NB\u2010UVB) phototherapy have not been well studied in vitiligo patients. An 11\u2010year nationwide population\u2010based retrospective cohort study was conducted using the Korean National Health Insurance claims database (2007\u20132017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the effects of long\u2010term NB\u2010UVB phototherapy on the risk of cardiovascular and cerebrovascular events in vitiligo patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included vitiligo patients with \u2265100 phototherapy sessions (phototherapy group, <jats:italic>n<\/jats:italic>\u00a0=\u00a03229) and &lt;3 phototherapy sessions (no phototherapy group, <jats:italic>n<\/jats:italic>\u00a0=\u00a09687), in which covariables with age, sex, insurance type and comorbidities such as diabetes, hypertension and hyperlipidemia were matched by 1\u00a0:\u00a03 propensity score matching. The outcomes of interest were cardiovascular (ischaemic heart disease and myocardial infarction) and cerebrovascular events (cerebrovascular infraction and haemorrhage). Cox proportional hazards models were used to assess the associations between NB\u2010UVB phototherapy and each event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The risk of cardiovascular or cerebrovascular events was significantly decreased in the phototherapy group compared with the no phototherapy group [hazard ratio (HR) 0.637, 95% confidence interval (CI) 0.523\u20130.776]. Subgroup analysis revealed that the risk of cardiovascular (HR: 0.682, 95% CI: 0.495\u20130.940) and cerebrovascular events (HR: 0.601, 95% CI: 0.470\u20130.769) were significantly lower in the phototherapy group than the no phototherapy group, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that long\u2010term NB\u2010UVB phototherapy could decrease the risk of cardiovascular and cerebrovascular events in patients with vitiligo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16830","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T19:24:02Z","timestamp":1595532242000},"page":"222-229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Both cardiovascular and cerebrovascular events are decreased following long\u2010term narrowband ultraviolet B phototherapy in patients with vitiligo: a propensity score matching analysis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5975-8519","authenticated-orcid":false,"given":"J.M.","family":"Bae","sequence":"first","affiliation":[{"name":"Department of Dermatology St. Vincent's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1660-010X","authenticated-orcid":false,"given":"Y.\u2010S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3166-3176","authenticated-orcid":false,"given":"E.H.","family":"Choo","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3162-6650","authenticated-orcid":false,"given":"M.\u2010Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"CNP Skin Clinic Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8650-1759","authenticated-orcid":false,"given":"J.Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1243-0094","authenticated-orcid":false,"given":"H.\u2010O.","family":"Kim","sequence":"additional","affiliation":[{"name":"Line Dermatology Clinic Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3631-0807","authenticated-orcid":false,"given":"Y.M.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60763-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2015.56.3.719"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.0002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.126"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14036414"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.11.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.10.043"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2360-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq069"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.2.150"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.15.1630"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.285.6346.919"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp496"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/10.4.337"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2018.11.002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-14-133"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12251"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23737"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2016.40.1.79"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2016.12.1.42"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2012.42.1.10"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)60827-6"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.207019"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.27"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.007394"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11567-5"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20543"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.308063"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13020"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2011.00575.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10883.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12768"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.1984"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14951"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15159"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.02.050"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.04.058"},{"key":"e_1_2_8_39_1","first-page":"1439","article-title":"Prospective investigation of 25(OH)D3 serum concentration following UVB narrow band phototherapy in patients with psoriasis and atopic dermatitis","volume":"36","author":"Weinhold A","year":"2016","journal-title":"Anticancer Res"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3050"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9040327"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.1870"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.06.067"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2015.02.005"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.12.034"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.16830","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16830","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.16830","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T18:18:10Z","timestamp":1693765090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.16830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,17]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/jdv.16830"],"URL":"https:\/\/doi.org\/10.1111\/jdv.16830","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,17]]},"assertion":[{"value":"2020-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}