{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T07:34:26Z","timestamp":1773041666863,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Genital warts are the most common sexually transmitted infection (STI) and are caused by human papillomavirus (HPV). Persistent anal infection by oncogenic genotypes of HPV is a determinant for anal cancer. Currently, anal cancer screening is not widely implemented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our aim is to evaluate the role of perianal warts as a risk marker for anal high\u2010risk (HR) HPV detection and anal dysplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this observational, retrospective, cohort study of attendees of a STI outpatient clinic between January 2010 and June 2018, all human immunodeficiency virus (HIV)\u2010positive men who have sex with men (MSM) who performed anal cytology, anal HPV DNA detection and anoscopy were included. A comparison was made between patients with and without perianal warts. Primary endpoint: proportion of patients with an abnormal anal cytology. Secondary endpoints: proportion of patients with (i) anal HR\u2010HPV detection; (ii) anal HPV 16 detection; (iii) abnormal anal biopsy; and (iv) anal high\u2010grade squamous intraepithelial lesion (HSIL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010eight individuals were included: 39 with perianal warts and 39 without perianal warts. Subjects with perianal warts more frequently had an abnormal anal cytology (71.8% vs. 38.5%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). This group also had a higher rate of anal HPV 16 detection (38.5% vs. 12.8%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). No differences were detected in the proportion of patients with anal HR\u2010HPV detection, with an abnormal anal biopsy or with anal HSIL. Perianal warts was an independent risk factor for an abnormal anal cytology (OR: 7.2) and for anal HPV 16 detection (OR: 6.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Given the high risk of anal cancer in HIV\u2010positive MSM, effective screening strategies are greatly needed. This study suggests that the presence of perianal warts is a suitable risk marker for anal HPV 16 detection and anal dysplasia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16834","type":"journal-article","created":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T18:28:45Z","timestamp":1595788125000},"page":"2613-2619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Perianal warts as a risk marker for anal high\u2010risk\u2010human papillomavirus (HPV) detection and HPV\u2010associated diseases"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9416-4388","authenticated-orcid":false,"given":"A.","family":"Cerejeira","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o EPE Porto Porto 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