{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T09:33:08Z","timestamp":1775813588353,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Stevens\u2013Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are associated with various sequelae. Chronic pain, one of these sequelae, has never been systematically evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives and methods<\/jats:title><jats:p>To assess the persistence of pain in a single\u2010centre cohort of 113 consecutive patients with SJS\/TEN. From this cohort, 81 patients were interviewed more than 1\u00a0year after the initial episode and included in the study. Data were collected according to standardized questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From the 81 interviewed patients, 52 patients (64%) were painless and 29 patients (36%) were painful. Chronic pain syndrome was associated with a more severe initial acute phase of the disease (larger extent of detachment, higher SCORTEN, increased rate of admission in ICU and complications, and longer hospital stay). Pain was mainly located at the level of eyes (55%), mouth and lower limbs (38\u201341%), with a moderate daily intensity on average (4.7\/10). The \u2018affective\u2019 descriptors prevailed over the \u2018sensory\u2019 descriptors, with the exception of burning and itching sensations. Finally, regarding provoked pain, mechanical allodynia (to brushing and pressure) was more marked than thermal allodynia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The persistence of chronic pain after SJS\/TEN is a common phenomenon. Sensory descriptors are consistent with sensitization of both small\u2010diameter nerve fibres (burning and itching sensations) and large\u2010diameter nerve fibres (mechanical allodynia), but the affective\u2010emotional components of pain largely predominate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Complex mechanisms lead to persistent pain as long\u2010term sequela of SJS\/TEN, among which mechanisms, psychological factors related to post\u2010traumatic stress disorder probably play a key role.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16891","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T19:51:58Z","timestamp":1597780318000},"page":"188-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Chronic pain: a long\u2010term sequela of epidermal necrolysis (Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis) \u2013 prevalence, clinical characteristics and risk factors"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0294-8239","authenticated-orcid":false,"given":"J.\u2010P.","family":"Lefaucheur","sequence":"first","affiliation":[{"name":"EA 4391, ENT (Excitabilit\u00e9 Nerveuse et Th\u00e9rapeutique) Facult\u00e9 de Sant\u00e9 de Cr\u00e9teil Universit\u00e9 Paris Est Cr\u00e9teil Cr\u00e9teil France"},{"name":"Unit\u00e9 de Neurophysiologie Clinique Service de Physiologie \u2013 Explorations Fonctionnelles H\u00f4pital Henri Mondor Assistance Publique \u2013 H\u00f4pitaux de Paris Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Valeyrie\u2010Allanore","sequence":"additional","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Henri Mondor Assistance Publique \u2013 H\u00f4pitaux de Paris Cr\u00e9teil France"},{"name":"Cabinet de Dermatologie Saint\u2010Mand\u00e9 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ng Wing Tin","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Neurophysiologie Clinique Service de Physiologie \u2013 Explorations Fonctionnelles H\u00f4pital Henri Mondor Assistance Publique \u2013 H\u00f4pitaux de Paris Cr\u00e9teil France"},{"name":"Service de Physiologie \u2010 Explorations Fonctionnelles H\u00f4pital Avicenne H\u00f4pitaux Universitaires Paris\u2010Seine\u2010Saint\u2010Denis Assistance Publique \u2013 H\u00f4pitaux de Paris Bobigny France"},{"name":"Inserm U1272 Universit\u00e9 Sorbonne Paris Nord Bobigny France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Abgrall","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Neurophysiologie Clinique Service de Physiologie \u2013 Explorations Fonctionnelles H\u00f4pital Henri Mondor Assistance Publique \u2013 H\u00f4pitaux de Paris Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Colin","sequence":"additional","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Henri Mondor Assistance Publique \u2013 H\u00f4pitaux de Paris Cr\u00e9teil France"},{"name":"Centre de R\u00e9f\u00e9rence des Dermatoses Bulleuses Toxiques et Toxidermies Graves ToxiBul H\u00f4pital Henri Mondor Assistance Publique \u2013 H\u00f4pitaux de Paris Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8954-499X","authenticated-orcid":false,"given":"C.","family":"Hajj","sequence":"additional","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Henri Mondor Assistance Publique \u2013 H\u00f4pitaux de Paris Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"de Prost","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Dermatoses Bulleuses Toxiques et Toxidermies Graves ToxiBul H\u00f4pital Henri Mondor Assistance Publique \u2013 H\u00f4pitaux de Paris Cr\u00e9teil France"},{"name":"Service de R\u00e9animation H\u00f4pital Henri Mondor Assistance Publique \u2013 H\u00f4pitaux de Paris Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Wolkenstein","sequence":"additional","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Henri Mondor Assistance Publique \u2013 H\u00f4pitaux de Paris Cr\u00e9teil France"},{"name":"Centre de R\u00e9f\u00e9rence des Dermatoses Bulleuses Toxiques et Toxidermies Graves ToxiBul H\u00f4pital Henri Mondor Assistance Publique \u2013 H\u00f4pitaux de Paris Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5383-7096","authenticated-orcid":false,"given":"S.","family":"Ingen\u2010Housz\u2010Oro","sequence":"additional","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Henri Mondor Assistance Publique \u2013 H\u00f4pitaux de Paris Cr\u00e9teil France"},{"name":"Centre de R\u00e9f\u00e9rence des Dermatoses Bulleuses Toxiques et Toxidermies Graves ToxiBul H\u00f4pital Henri Mondor Assistance Publique \u2013 H\u00f4pitaux de Paris Cr\u00e9teil France"},{"name":"EA 7379 EpiDermE (Epid\u00e9miologie en Dermatologie et Evaluation des Th\u00e9rapeutiques) Facult\u00e9 de Sant\u00e9 de Cr\u00e9teil Universit\u00e9 Paris\u2010Est Cr\u00e9teil Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8400-4310","authenticated-orcid":false,"given":"O.","family":"Chosidow","sequence":"additional","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Henri Mondor Assistance Publique \u2013 H\u00f4pitaux de Paris Cr\u00e9teil France"},{"name":"Centre de R\u00e9f\u00e9rence des Dermatoses Bulleuses Toxiques et Toxidermies Graves ToxiBul H\u00f4pital Henri Mondor Assistance Publique \u2013 H\u00f4pitaux de Paris Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30378-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-018-0793-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.10.058"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18424"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18387"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18023"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13505"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17267"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.12.010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2003.12.024"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(87)91074-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(92)90112-O"},{"key":"e_1_2_7_14_1","first-page":"129","article-title":"Pain assessment: global use of the Brief Pain Inventory","volume":"23","author":"Cleeland CS","year":"1994","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00061.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700068"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098611404094"},{"key":"e_1_2_7_18_1","first-page":"711","article-title":"Chronic pain types differ in their reported prevalence of post \u2010traumatic stress disorder (PTSD) and there is consistent evidence that chronic pain is associated with PTSD: An evidence\u2010based structured systematic review","volume":"18","author":"Fishbain DA","year":"2017","journal-title":"Pain Med"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2017.12.262"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/20008198.2017.1375337"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18746"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2019.07.015"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14799"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-24019"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00007-X"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.180"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00025.2008"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70143-5"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.09.030"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16339"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1319"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02874556"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1203"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2016.05.016"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2011.05.029"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2020.01.361"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.9740\/mhc.2019.11.373"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/20008198.2020.1729633"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.16891","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16891","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.16891","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T18:18:47Z","timestamp":1693765127000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.16891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,22]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/jdv.16891"],"URL":"https:\/\/doi.org\/10.1111\/jdv.16891","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,22]]},"assertion":[{"value":"2020-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}