{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:34:12Z","timestamp":1792028052552,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is no universally accepted protocol of topical wound care after cutaneous surgical procedures. The current practice is to use petrolatum\u2010based products, commonly containing topical antibiotics. The rise in antibiotic\u2010resistant bacteria and increased risk of allergic and contact dermatitis due to the use of topical antibiotics is well established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the prevalence of contact dermatitis, the infection rate and the subjective measures of healing of a novel, antibiotic\u2010free, film\u2010forming silicone\u2010based wound dressing to a topical triple antibiotic petrolatum\u2010based ointment in patients undergoing invasive dermatological interventions in two arms: (1) Mohs micrographic surgery (MMS) and (2) a combination of various routine dermatologic surgical procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The 231 patients were enrolled in this open\u2010label, randomized, single\u2010blinded study. Patients applied the products immediately after surgery and daily afterwards. Clinicians evaluated the surgical site for infection or contact dermatitis at all follow\u2010up visits. Acute wound healing progression was assessed using a rating scale against clinical experience and expected results from \u22124 (much worse) to +4 (much better).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Contact dermatitis was significantly decreased in the wound dressing group compared to the topical antibiotic group (0 vs 15.9%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). There was no difference between the study arms (Mohs vs. non\u2010Mohs, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.242). Infection rate was not significantly different between the groups (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05) and between the study arms (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). Assessor\u2010rated secondary outcomes like healing time, healing quality, erythema and new tissue quality were significantly better in the wound dressing group, while comfort and perceived overall satisfaction were better in the antibiotic group. Patient\u2010rated outcomes did not show any difference between groups and between study arms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The wound dressing used in this study is a topical silicone gel preparation and presents a viable alternative to topical antibiotics for postoperative wound care without enhancing the risk of infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16965","type":"journal-article","created":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T03:12:48Z","timestamp":1601089968000},"page":"247-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Comparing the use of a novel antibiotic\u2010free film\u2010forming topical wound dressing versus a topical triple antibiotic in dermatologic surgical procedures including Mohs micrographic surgery"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4280-9380","authenticated-orcid":false,"given":"A.V.","family":"Benedetto","sequence":"first","affiliation":[{"name":"Dermatology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA"},{"name":"Dermatologic SurgiCenter Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.P.","family":"Staidle","sequence":"additional","affiliation":[{"name":"Skin Cancer &amp; Dermatology Institute Reno NV USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Schoenfeld","sequence":"additional","affiliation":[{"name":"Pennsylvania Dermatology Partners Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.A.","family":"Benedetto","sequence":"additional","affiliation":[{"name":"Dermatologic SurgiCenter Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.X.","family":"Benedetto","sequence":"additional","affiliation":[{"name":"Dermatologic SurgiCenter Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001952"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2007.01.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02122.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2009.01256.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.03.042"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70158-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1995.tb00255.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.3.505"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31610"},{"key":"e_1_2_7_11_1","first-page":"127","article-title":"Anaphylactic reaction to bacitracin ointment","volume":"83","author":"Cronin H","year":"2009","journal-title":"Cutis"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2006.04.010"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2008.07094"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2005.06.009"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2010.01.025"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1106.041146"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03540120050033"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.04.031"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.10.038"},{"issue":"1","key":"e_1_2_7_20_1","first-page":"S1","article-title":"The safety, efficacy, and tolerability of a novel silicone gel dressing following dermatological surgery","volume":"10","author":"Sandhofer M","year":"2012","journal-title":"Skinmed"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200208000-00031"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12366"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13066"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001001"},{"key":"e_1_2_7_25_1","volume-title":"WinEpi: Working In Epidemiology. 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