{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:29:30Z","timestamp":1785281370529,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>IncobotulinumtoxinA has been previously used for the treatment of lateral periorbital lines (crow\u2019s feet). However, a standardized injection technique has not been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the efficacy and effect duration of two injection techniques of incobotulinumtoxinA for crow\u2019s feet treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010eight patients with crow\u2019s feet were recruited and randomly assigned to receive bilateral treatments using either a 3\u2010point intramuscular or a 6\u2010point intradermal injection technique (8\u201312 units of incobotulinumtoxinA on each side). Improvement was assessed at 1, 2, 4, 8, 12, 16, 20 and 24\u00a0weeks postinjection. An objective evaluation was assessed by the indentation index using a 3D camera and a subjective evaluation was assessed by a blinded dermatologist using the Flynn validated assessment scale (FVAS) for the upper face. The patients assessed the results using the Global Aesthetic Improvement Scale (GAIS). Side\u2010effects were evaluated at each visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After treatment, a significantly greater reduction in the indentation index of periorbital wrinkles on the 3\u2010point intramuscular injection side compared with the 6\u2010point intradermal injection side was observed at 8, 12, and 16\u00a0weeks. The results from the FVAS and GAIS scores showed significantly longer median times to relapse of the periorbital wrinkle for the 3\u2010point intramuscular injection compared with the 6\u2010point intradermal injection. Pain and bruising were slightly greater with the 6\u2010point intradermal technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study reaffirmed the efficacy of incobotulinumtoxinA for the treatment of crow\u2019s feet. The 3\u2010point intramuscular injection technique yielded greater efficacy and longer duration of action than the 6\u2010point intradermal injection technique.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16997","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T19:30:35Z","timestamp":1602963035000},"page":"256-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Different injection patterns of incobotulinumtoxinA for crow\u2019s feet: a split\u2010face comparative study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7328-939X","authenticated-orcid":false,"given":"V.","family":"Vachiramon","sequence":"first","affiliation":[{"name":"Division of Dermatology Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok 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