{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T09:44:12Z","timestamp":1779183852117,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T00:00:00Z","timestamp":1607126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about skin\u2010related complications in Klippel\u2013Trenaunay syndrome (KTS), a complex vascular anomaly defined by capillary malformation (CM), venous malformation (VM)\u00a0\u00b1\u00a0lymphatic malformation (LM) and limb overgrowth. Reported skin\u2010related complications of KTS include ulceration, vascular ectasias (blebs), bleeding and infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the spectrum, prevalence and predictors of skin\u2010related complications in KTS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of 410 patients fulfilling KTS criteria was performed to assess for the presence of skin\u2010related complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Skin\u2010related complications were present in 45% of patients. Most prevalent were CM\u2010related complications including blebs, bleeding, thickening (25%), cellulitis (22%) and ulceration (21%). Features positively associated with skin\u2010related complications were presence of LM (OR 17.17; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), VM on the buttocks\/perineum\/genitalia (OR 1.92; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009), CM on the feet (OR 1.77; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.039) and male sex (OR 1.63; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.034). Features negatively associated with skin\u2010related complications were CM on the trunk (OR 0.59; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.029) and tissue hypertrophy of the hands (OR 0.27; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Skin\u2010related complications affect nearly half of patients with KTS. Those with lymphatic involvement or malformation presence in the undergarment area or feet are most at risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16999","type":"journal-article","created":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T20:12:11Z","timestamp":1603051931000},"page":"517-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Skin\u2010Related complications of Klippel\u2013Trenaunay Syndrome: a retrospective review of 410 patients"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7129-4032","authenticated-orcid":false,"given":"K.R.","family":"Anderson","sequence":"first","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN USA"},{"name":"Department of Pediatric and Adolescent Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.J.","family":"Schoch","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Florida Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.M.","family":"Lohse","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.J.","family":"Driscoll","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.","family":"Tollefson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN USA"},{"name":"Department of Pediatric and Adolescent Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,5]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"ISSVA Classification of Vascular Anomalies \u00a92018 International Society for the Study of Vascular Anomalies. 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