{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T08:46:55Z","timestamp":1784278015625,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO 303"],"award-info":[{"award-number":["KFO 303"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2167"],"award-info":[{"award-number":["EXC 2167"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although the association of bullous pemphigoid (BP) and psoriasis is well\u2010established, the clinical and immunological features of patients with coexisting BP and psoriasis are yet to be investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to estimate the prevalence of psoriasis amongst patients with BP and to elucidate the clinical and immunological characteristics of BP patients with comorbid psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study including all consecutive patients diagnosed with BP throughout the years 2009\u20132019 in a tertiary referral centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study encompassed 273 patients with BP, of whom 11 (4.0%; 95% CI, 2.3\u20137.1%) had comorbid psoriasis. The onset of psoriasis preceded that of BP in 81.8% of patients by a median (range) latency of 26.5 (5.0\u201334.0) years. Compared to BP patients without psoriasis, those with BP and comorbid psoriasis were significantly younger at the onset of BP [71.8 (9.3) vs. 79.4 (9.8) years; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.023], had a milder erosive phenotype [erosion\/blister BPDAI mean (SD)score; 5 (4.1) vs. 22.3 (15.2); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025], lower levels of anti\u2010BP180 NC16A serum autoantibodies [236.6 (266.3) vs. 556.2 (1323.6) U\/mL; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008] and a higher prevalence of isolated linear C3 deposits (36.4% vs. 14.1%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.043) and a lower prevalence of linear immunoglobulin G deposits (36.4% vs. 68.7%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025) along the dermal\u2013epidermal junction by direct immunofluorescence microscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with BP and comorbid psoriasis present at a younger age with milder erosive phenotype and lower levels of pathogenic autoantibodies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17013","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T18:09:11Z","timestamp":1603562951000},"page":"981-987","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Patients with bullous pemphigoid and comorbid psoriasis present with less blisters and lower serum levels of anti\u2010BP180 autoantibodies"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0183-0375","authenticated-orcid":false,"given":"S.","family":"St\u00e4nder","sequence":"first","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9971-9151","authenticated-orcid":false,"given":"K.","family":"Kridin","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"254","article-title":"Psoriasis with superimposed bullous eruption","volume":"20","author":"Bloom D","year":"1929","journal-title":"Arch 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