{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:53:08Z","timestamp":1788187988567,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Topical therapy is the mainstay of treatment for the majority of patients with psoriasis vulgaris (chronic plaque psoriasis), with combinations of vitamin D analogues and glucocorticoids having been shown to negate many of the negative effects associated with either monocomponent individually. Following the established efficacy of fixed\u2010dose combination calcipotriol (Cal; 50\u00a0\u00b5g\/g) plus betamethasone dipropionate (BD; 0.5\u00a0mg\/g) ointment and gel formulations, a novel Cal\/BD foam formulation was developed. When applied, Cal\/BD foam forms a supersaturated solution on the skin, increasing the penetration and bioavailability of Cal and BD. Early data indicate that this results in improved efficacy outcomes versus Cal\/BD ointment, without negatively affecting safety outcomes (such as the incidence\/severity of side effects or impacted calcium homeostasis or hypothalamic\u2010pituitary\u2010adrenal axis). This article discusses the potency and absorption of fixed\u2010dose combination Cal\/BD foam, as well as the positive early efficacy and safety data associated with its utilisation in the treatment of psoriasis vulgaris.<\/jats:p>","DOI":"10.1111\/jdv.17027","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T08:02:48Z","timestamp":1614067368000},"page":"5-9","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Early efficacy and safety data with fixed\u2010dose combination calcipotriol\/betamethasone dipropionate foam attributed to mechanism of absorption and steroid potency"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3743-135X","authenticated-orcid":false,"given":"Y.","family":"Tada","sequence":"first","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo 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