{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:11:25Z","timestamp":1777871485878,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The physical symptoms of psoriasis vulgaris (chronic plaque psoriasis), such as itch and itch\u2010related sleep loss, and the psychological impact of visible plaques on the body, all contribute to significantly reduced health\u2010related quality of life (HRQoL) in patients with psoriasis. In fact, the deterioration of HRQoL in patients with psoriasis is similar to patients with other chronic conditions, such as cancer and cardiovascular diseases. Rapid and effective improvements in HRQoL and itch\u2010related outcomes would therefore be highly valued by patients and may even improve adherence to treatment. In this article, we summarise previously published data assessing the impact of fixed\u2010dose combination calcipotriol 50\u00a0\u00b5g\/g plus betamethasone dipropionate 0.5\u00a0mg\/g cutaneous foam (Cal\/BD foam) on itch relief, quality of sleep, onset of action and HRQoL. Findings across multiple analyses indicate that Cal\/BD foam provides significant improvements in itch, itch\u2010related sleep loss and HRQoL compared with vehicle foam or Cal\/BD gel comparators. Additionally, the benefits of Cal\/BD foam were recorded earlier than these comparators, often within 1\u00a0week of treatment, indicating a rapid onset of action. With the published data to hand, it is clear that Cal\/BD foam provides significant improvements in the outcomes that matter most to patients and should be considered an effective topical treatment for psoriasis.<\/jats:p>","DOI":"10.1111\/jdv.17085","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T08:02:48Z","timestamp":1614067368000},"page":"20-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fixed\u2010dose combination calcipotriol\/betamethasone dipropionate foam provides a rapid onset of action, effective itch relief and improves patient quality of life"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8349-4530","authenticated-orcid":false,"given":"A.","family":"Jalili","sequence":"first","affiliation":[{"name":"Dermatology &amp; Skin Care B\u00fcrgenstock Medical Center Obb\u00fcrgen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6303-1822","authenticated-orcid":false,"given":"G.","family":"Yosipovitch","sequence":"additional","affiliation":[{"name":"Dr Phillip Frost Department of Dermatology and Cutaneous Surgery &amp; Miami Itch Center Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.033217"},{"key":"e_1_2_8_3_1","first-page":"167","article-title":"A systematic literature review to compare quality of life in psoriasis with other chronic diseases using EQ\u20105D\u2010derived utility values","volume":"6","author":"M\u00f8ller AH","year":"2015","journal-title":"Patient Relat Outcome Meas"},{"key":"e_1_2_8_4_1","first-page":"981","article-title":"The aerosol foam formulation of the fixed combination calcipotriene plus betamethasone dipropionate improves the health\u2010related quality of life in patients with psoriasis vulgaris: results from the randomized PSO\u2010FAST study","volume":"15","author":"Leonardi C","year":"2016","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.02.039"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15450"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-4-35"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-017-0192-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.5538"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03829.x"},{"key":"e_1_2_8_11_1","first-page":"221","article-title":"Itching in patients suffering from psoriasis","volume":"10","author":"Szepietowski JC","year":"2002","journal-title":"Acta Dermatovenerol Croat"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1201\/b16573-5"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15393"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1637-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02591.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0851"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"13030\/qt1x16v3d","DOI":"10.5070\/D32110028943","article-title":"Increased severity of itching, pain, and scaling in psoriasis patients is associated with increased disease severity, reduced quality of life, and reduced work productivity","volume":"21","author":"Korman NJ","year":"2015","journal-title":"Dermatol Online J"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-7-62"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S134864"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1193"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1993.tb02790.x"},{"key":"e_1_2_8_22_1","first-page":"280","article-title":"The impact of psoriasis on quality of life: results of a 1998 National Psoriasis Foundation patient\u2010membership survey","volume":"137","author":"Krueger G","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12174"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15398"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17027"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17028"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13859"},{"key":"e_1_2_8_28_1","first-page":"119","article-title":"Fixed\u2010combination calcipotriene plus betamethasone dipropionate aerosol foam is well tolerated in patients with psoriasis vulgaris: pooled data from three randomized controlled studies","volume":"15","author":"Menter A","year":"2017","journal-title":"Skin Med"},{"key":"e_1_2_8_29_1","first-page":"1468","article-title":"Efficacy and safety of calcipotriene plus betamethasone dipropionate aerosol foam in patients with psoriasis vulgaris \u2013 a randomized phase III study (PSO\u2010FAST)","volume":"14","author":"Leonardi C","year":"2015","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.12.029"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13947"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1083935"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12207"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2004.09113.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2018.3302"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1717417"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17084"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-011-9903-x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05492.x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.82482"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.17085","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.17085","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.17085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T20:22:38Z","timestamp":1693599758000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.17085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":39,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/jdv.17085"],"URL":"https:\/\/doi.org\/10.1111\/jdv.17085","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"2020-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}