{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:25:35Z","timestamp":1787973935138,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment of moderate\u2010to\u2010severe atopic dermatitis (AD) in the elderly may be challenging, due to side\u2010effects of traditional anti\u2010inflammatory drugs and to comorbidities often found in this age group. Furthermore, efficacy and safety of innovative drugs such as dupilumab are not yet well known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>A multicentre retrospective, observational, real\u2010life study on the efficacy and safety of dupilumab was conducted in a group of patients aged \u226565\u00a0years and affected by severe AD. Their main clinical features were also examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data of elderly patients with severe (EASI \u226524) AD treated with dupilumab at label dosage for 16\u00a0weeks were retrospectively collected. Treatment outcome was assessed by comparing objective (EASI) and subjective (P\u2010NRS, S\u2010NRS and DLQI) scores at baseline and after 16\u00a0weeks of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two hundred and seventy\u2010six patients were enrolled in the study. They represented 11.37% of all patients with severe AD. Flexural eczema was the most frequent clinical phenotype, followed by prurigo nodularis. The coexistence of more than one phenotype was found in 63\/276 (22.82%) subjects. Data on the 16\u2010week treatment with dupilumab were available for 253 (91.67%) patients. Efficacy of dupilumab was demonstrated by a significant reduction of all the scores. No statistically significant difference regarding efficacy was found in elderly patients when compared to the group of our AD patients aged 18\u201364\u00a0years, treated with dupilumab over the same period. Furthermore, only 18 (6.52%) patients discontinued the drug due to inefficacy. Sixty\u2010one (22.51%) patients reported adverse events, conjunctivitis and flushing being the most frequent. One (0.36%) patient only discontinued dupilumab due to an adverse event.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Therapy with dupilumab led to a significant improvement of AD over a 16\u2010week treatment period, with a good safety profile. Therefore, dupilumab could be considered as an efficacious and safe treatment for AD also in the elderly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.17094","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T06:33:37Z","timestamp":1608273217000},"page":"958-964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Dupilumab therapy of atopic dermatitis of the elderly: a multicentre, real\u2010life study"],"prefix":"10.1111","volume":"35","author":[{"given":"C.","family":"Patruno","sequence":"first","affiliation":[{"name":"Department of Health Sciences University Magna Graecia of Catanzaro Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3309-8190","authenticated-orcid":false,"given":"M.","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences Vincenzo Tiberio University of Molise Campobasso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Argenziano","sequence":"additional","affiliation":[{"name":"Dermatology Unit University of Campania Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1957-6600","authenticated-orcid":false,"given":"K.","family":"Peris","sequence":"additional","affiliation":[{"name":"Dermatology University of the Sacred Heart Rome Italy"},{"name":"Fondazione Policlinico Universitario A.Gemelli IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ortoncelli","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8548-0493","authenticated-orcid":false,"given":"G.","family":"Girolomoni","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Medicine University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Offidani","sequence":"additional","affiliation":[{"name":"Dermatology Unit Department of Clinical and Molecular Sciences Polytechnic Marche University Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.F.","family":"Amoruso","sequence":"additional","affiliation":[{"name":"AO Cosenza UOC Dermatologia Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rossi","sequence":"additional","affiliation":[{"name":"UO Dermatologia ASST Spedali Civili di Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-8141","authenticated-orcid":false,"given":"L.","family":"Stingeni","sequence":"additional","affiliation":[{"name":"Dermatology Section Department of Medicine University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6210-4479","authenticated-orcid":false,"given":"G.","family":"Malara","sequence":"additional","affiliation":[{"name":"Struttura Complessa di Dermatologia Grande Ospedale Metropolitano \u2018Bianchi Melacrino Morelli\u2019 Reggio Calabria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Grieco","sequence":"additional","affiliation":[{"name":"Dermatology Unit Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Foti","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology University of Bari Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gattoni","sequence":"additional","affiliation":[{"name":"Dermatologic Department S. Andrea Hospital Vercelli Vercelli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Loi","sequence":"additional","affiliation":[{"name":"Dermatology Department of Experimental, Diagnostic and Specialty Medicine University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Iannone","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Talamonti","sequence":"additional","affiliation":[{"name":"Dermatology Unit Policlinico Tor Vergata Department of Systemic Medicine Tor Vergata University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Stinco","sequence":"additional","affiliation":[{"name":"Department of Medicine Institute of Dermatology University of Udine Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Rongioletti","sequence":"additional","affiliation":[{"name":"Unit of Dermatology Department of Medical Sciences and Public Health University of Cagliari Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.D.","family":"Pigatto","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Odontoiatric Science IRCCS Ospedale Ortopedico Galeazzi Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cristaudo","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatologic Institute IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Nettis","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation School and Chair of Allergology and Clinical Immunology University of Bari \u2010 Aldo Moro Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Corazza","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Infectious Diseases Department of Medical Sciences University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Guarneri","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Dermatology University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Amerio","sequence":"additional","affiliation":[{"name":"Dermatologic Clinic SS. 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