{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T18:17:10Z","timestamp":1779905830722,"version":"3.53.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In contrast to adults, only limited data are available on the human papillomavirus (HPV)\u2010type spectrum in anogenital warts (AGW) of children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to evaluate the HPV\u2010type spectrum in AGW of prepubertal children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; methods<\/jats:title><jats:p>In a retrospective German multicentre study, HPV genotyping was performed in AGW biopsies of 55 1\u2010 to 12\u2010year\u2010old children using HPV group\u2010specific PCRs followed by hybridization with type\u2010specific probes or sequence analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Human papillomavirus\u2010DNA was found in 53 of the 55 AGW. In 58.5% (31\/53) of the HPV\u2010positive AGW, mucosal HPV types were detected. HPV6 (27\/53, 50.9%) was the predominant type. 43.4% (23\/53) of the lesions were induced by cutaneous HPV types (HPV2, HPV27, HPV57). Mucosal HPV types were significantly more common in children under 5\u00a0years of age than in children 5\u00a0years of age and older (22\/25, 88.0% [95% CI: 70.0\u201395.8] vs. 9\/28, 32.1% [95% CI: 17.9\u201350.7], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In contrast, cutaneous HPV types were significantly more prevalent in the 5\u2010 to 12\u2010year age group (4\/25, 16.0% [95% CI 6.4\u201334.7] vs. 19\/28, 67.9% [95% CI 49.3\u201382.1], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anogenital warts in 5\u2010 to 12\u2010year\u2010old children are frequently associated with cutaneous HPV types, possibly due to horizontal transmission. HPV typing, in addition to comprehensive clinical and psychosocial evaluation, can potentially help in the assessment of these cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17114","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T06:15:24Z","timestamp":1610691324000},"page":"1219-1225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Human Papillomavirus\u2010type distribution in anogenital lesions of prepubertal children"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5600-0195","authenticated-orcid":false,"given":"S.A.","family":"Braun","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Muenster Muenster Germany"},{"name":"Department of Dermatology Medical Faculty Heinrich\u2010Heine University Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Silling","sequence":"additional","affiliation":[{"name":"Institute of Virology National Reference Center for Papilloma and Polyomaviruses University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Schloer","sequence":"additional","affiliation":[{"name":"Center for Molecular Biology of Inflammation Institute of Medical Biochemistry University of Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.C.","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Allergology, und Dermatosurgery HELIOS University Hospital Wuppertal University of Witten\u2010Herdecke Wuppertal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Fritzen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology HELIOS Hospital Krefeld Krefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Oellig","sequence":"additional","affiliation":[{"name":"Institute of Pathology M\u00fclheim a.d.R. 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