{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:23:37Z","timestamp":1788535417390,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Adapalene\u2013benzoyl peroxide (A\u2010BPO) is a first\u2010line topical treatment for acne vulgaris.\n                      <jats:italic>In vivo<\/jats:italic>\n                      reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) detect micromorphological changes over time and visualize transfollicular delivery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To visualize temporal, subclinical effects of A\u2010BPO on acne micromorphology using RCM and OCT, and evaluate their impact on transfollicular delivery of microparticulate carrier systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifteen patients with mild to moderate acne received a 6\u2010week course of A\u2010BPO. Micromorphological changes were evaluated at time 0, 3 and 6\u00a0weeks with RCM (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01190 images) and OCT (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0210 scans). Transfollicular delivery of microparticles was assessed at baseline and week 6.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>In vivo<\/jats:italic>\n                      imaging visualized steady normalization of skin micromorphology in response to A\u2010BPO over 6\u00a0weeks, including decreased hyperkeratinization of follicular borders (RCM median decrease \u221271.2%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), reduced intrafollicular keratinous content (RCM median decrease \u221247.7%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) and increased epidermal thickness (OCT median increase of 25.25%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Imaging visualized microparticles in the follicular unit. Despite a visible reduction in keratin and sebum, transfollicular microparticle delivery appeared unaffected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Reflectance confocal microscopy and OCT detect A\u2010BPO\u2010induced changes in micromorphology and visualize transfollicular microparticle delivery. Keratolysis and sebolysis did not have a measurable effect on transfollicular delivery of microparticles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.17140","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T21:26:47Z","timestamp":1611869207000},"page":"1377-1385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Subclinical effects of adapalene\u2010benzoyl peroxide: a prospective\n                    <i>in vivo<\/i>\n                    imaging study on acne micromorphology and transfollicular delivery"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3329-2516","authenticated-orcid":false,"given":"C.S.K.","family":"Fuchs","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Copenhagen Bispebjerg and Frederiksberg Hospital Copenhagen 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