{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:48:15Z","timestamp":1792439295048,"version":"4.5.0"},"reference-count":81,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alopecia areata is the third most common cause of dermatology consultations in children but the treatment of paediatric alopecia areata remains challenging. A systematic review of the literature about the treatment of alopecia areata in children (\u226418\u00a0years old) was performed on 11 May 2020 by searching the PubMed, Scopus and EBSCO databases. The terms used for the search were: \u2018alopecia areata\u2019, \u2018alopecia totalis\u2019 or \u2018alopecia universalis\u2019 combined with \u2018paediatric\u2019, \u2018children\u2019 or \u2018childhood\u2019. A total of 89 articles were included in final evaluation. The most commonly assessed treatment options in paediatric alopecia areata were topical immunotherapy (response rate in monotherapy: 54%; 187\/345) intralesional glucocorticosteroids (75%; 211\/280), systemic glucocorticosteroids (73%; 102\/140), and anthralin (42%; 31\/74). Topical glucocorticosteroids (81%; 35\/43), systemic Janus kinase (JAK) inhibitors (90%; 27\/30), topical calcineurin inhibitors (42%; 8\/19), topical JAK inhibitors (65%; 11\/17), PUVA therapy (56%; 9\/16) and 308\u2010nm excimer laser (77%; 10\/13) were also evaluated. Additionally, evaluation in smaller numbers of paediatric patients included methotrexate (100%; 10\/10), topical minoxidil (44%; 4\/9) and cyclosporine (83%; 5\/6). There were limited data considering children with alopecia areata treated with azathioprine, hydroxychloroquine, topical sildenafil, topical prostaglandin analogues, fractional carbon dioxide laser, leflunomide, mesalazine, apremilast, dupilumab, ustekinumab, efalizumab, botulinum toxin, and compound glycyrrhizin. On the basis of the limited data available glucocorticosteroids (systemic, intralesional or topical) and JAK inhibitors (systemic or topical) may be considered the best documented and most effective treatment options in alopecia areata in children. There are no sufficient paediatric data to compare treatment safety and relapse rates in these therapeutic modalities.<\/jats:p>","DOI":"10.1111\/jdv.17187","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T15:19:31Z","timestamp":1614266371000},"page":"1299-1308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Therapeutic management in paediatric alopecia areata: A systematic review"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4984-3589","authenticated-orcid":false,"given":"A.","family":"Wa\u015bkiel\u2010Burnat","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ko\u0142odziejak","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Warsaw Warsaw 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