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With NDM and mixed infection (dermatophytes plus NDM) onychomycosis on the rise, accurate clinical diagnosis along with mycological tests is recommended. Systemic antifungal agents such as itraconazole and terbinafine (e.g. pulse regimen: 1 pulse\u00a0=\u00a0every day for one week, followed by no treatment for three weeks) have shown efficacy in treating onychomycosis caused by various NDMs such as <jats:italic>Aspergillus<\/jats:italic> spp., <jats:italic>Fusarium<\/jats:italic> spp., <jats:italic>Scopulariopsis brevicaulis,<\/jats:italic> and <jats:italic>Onychocola canadensis<\/jats:italic>. Studies investigating topical therapy and devices for NDM onychomycosis are limited. The emergence of antifungal resistance necessitates the incorporation of antifungal susceptibility testing into diagnosis when possible, for the management of recalcitrant infections. Case studies documented in the literature show newer azoles such as posaconazole and voriconazole as sometimes effective in treating resistant NDM onychomycosis. Treatment with broad\u2010spectrum antifungal agents (e.g. itraconazole and efinaconazole) and other combination therapy (oral\u00a0+\u00a0oral and\/or oral\u00a0+\u00a0topical) may be considerations in the management of NDM onychomycosis.<\/jats:p>","DOI":"10.1111\/jdv.17240","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T01:40:13Z","timestamp":1616636413000},"page":"1628-1641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Nondermatophyte mould onychomycosis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8664-7723","authenticated-orcid":false,"given":"A.K.","family":"Gupta","sequence":"first","affiliation":[{"name":"Mediprobe Research Inc. 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