{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:06:22Z","timestamp":1778645182085,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Telogen effluvium is a hair loss disorder occurring about 3\u00a0months after a triggering event. The acute form impairs quality of life, but spontaneous recovery usually begins 3\u20136\u00a0months after identification and elimination of the cause, with complete recovery taking around 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the effectiveness and safety of a hair lotion containing creatine, acetyl tetrapeptide\u20102 and B vitamins for reducing hair loss in acute telogen effluvium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this open, randomized, controlled study (NCT04652232), women with acute telogen effluvium from two clinical centres were randomly allocated to receive either the lotion and a mild shampoo (intervention group), or the mild shampoo alone (controls). Hair growth parameters and hair loss were measured from phototrichograms at weeks (W) 1, 4, 8 and 16, and through investigator assessments of standardized photographs at W1 and W16. The primary criterion was the change in anagen to telogen (A\/T) ratio between W1 and W16.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred women (aged 19\u201350\u00a0years) were included (intervention group, <jats:italic>N<\/jats:italic>\u00a0=\u00a051; controls, <jats:italic>N<\/jats:italic>\u00a0=\u00a049). Compared to baseline, the A\/T ratio was higher at W16 in both groups and was significantly higher at both W4 and W8 in the intervention group, compared to only at W8 in controls. Significant decreases in telogen hair density were seen at all time points in the intervention group, compared to only at W16 in controls, and the between\u2010group difference was significant at W8 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0465). A larger reduction in the total number of hairs shed was observed at W8 in the intervention group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0392). Investigator\u2010assessed scores showed improvements in hair density for the intervention group. Global tolerance of the lotion was excellent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The lotion tested had a significant impact on hair loss in women with acute telogen effluvium and appeared to accelerate recovery from this condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17245","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T11:56:05Z","timestamp":1634817365000},"page":"12-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessment of the effects of a hair lotion in women with acute telogen effluvium: a randomized controlled study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7634-5860","authenticated-orcid":false,"given":"V.","family":"Turlier","sequence":"first","affiliation":[{"name":"Pierre Fabre Dermo\u2010Cosme\u0301tique Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.\u2010S.","family":"Darde","sequence":"additional","affiliation":[{"name":"Pierre Fabre Dermo\u2010Cosme\u0301tique Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Loustau","sequence":"additional","affiliation":[{"name":"Pierre Fabre Dermo\u2010Cosme\u0301tique Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Mengeaud","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Pierre Fabre Laboratory Lavaur France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.331.7522.951"},{"key":"e_1_2_7_3_1","article-title":"Telogen effluvium: a review","volume":"9","author":"Malkud S","year":"2015","journal-title":"J Clin Diagn 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