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Patients with AD are at greater risk of comorbidities such as attention\u2010deficit hyperactivity disorder as well as other atopic diseases. Early\u2010onset AD cases typically improve or resolve in late childhood; however, it is proposed that the prevalence of persistent or adult\u2010onset AD is higher than previously thought. Basic therapy consists of emollient application and trigger avoidance, and when insufficient, topical corticosteroids (TCS) are the first\u2010line treatment. However, corticophobia\/steroid aversion and TCS side\u2010effects, particularly on sensitive skin areas, lead to low compliance and insufficient disease control. Several long\u2010 and short\u2010term randomized controlled and daily practice studies have demonstrated that topical calcineurin inhibitors, such as pimecrolimus, have similar anti\u2010inflammatory effects to low\u2010to\u2010medium strength TCS, reduce pruritus and improve the quality of life of patients. 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