{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:40:18Z","timestamp":1791510018209,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The influence of cutaneous cellular infiltration on the phenotype of bullous pemphigoid (BP) remains to be established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the main histopathological characteristics of patients with BP and to assess the association between the composition of lesional inflammatory infiltrate and the various clinical, immunological and immunopathological aspects of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study encompassing patients diagnosed with BP throughout the years 2009\u20132020 in a specialized tertiary referral centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study encompassed 136 patients with BP, of whom 27 (19.9%) demonstrated a cell\u2010poor inflammatory infiltrate in lesional skin specimens. Overall, 78 (57.4%), 71 (52.2%) and 5 (3.7%) specimens were found to include eosinophil\u2010predominant, lymphocyte\u2010predominant and neutrophil\u2010predominant inflammatory infiltrates, respectively. Relative to the remaining patients with BP, those with an eosinophil\u2010predominant inflammatory infiltrate had higher (90.8% vs. 77.2%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.030) whilst those with a cell\u2010poor inflammatory infiltrate lower (70.3% vs. 88.7%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.017) seropositivity of anti\u2010BP180 NC16A IgG. The latter subgroup presented with higher prevalence of mucosal involvement (25.9% vs. 8.3%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.011) and a non\u2010inflammatory clinical phenotype (50.0% vs. 17.1%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.041). Patients with lymphocyte\u2010predominant inflammatory infiltrate manifested with higher severity BPDAI scores and a lower frequency of the non\u2010inflammatory subtype (11.1% vs. 36.4%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.035), whilst those with a neutrophilic infiltrate presented with lower mean (SD) levels of anti\u2010BP180 NC16A IgG [269.3 (227.6) vs. 722.7 (1499.6) U\/mL;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.003].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Eosinophil\u2010predominance and high cellularity in the lesional inflammatory infiltrate of BP skin are associated with increased seropositivity of anti\u2010BP180 NC16A IgG. Lymphocyte\u2010predominant infiltrates predict a more severe phenotype, pointing towards a pathogenic role of autoreactive lymphocytes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.17303","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T09:23:53Z","timestamp":1619342633000},"page":"1702-1711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The impact of lesional inflammatory cellular infiltrate on the phenotype of bullous pemphigoid"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0183-0375","authenticated-orcid":false,"given":"S.","family":"St\u00e4nder","sequence":"first","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.M.","family":"Hammers","sequence":"additional","affiliation":[{"name":"Department of 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