{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:40:01Z","timestamp":1763037601109,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While clustering of bullous pemphigoid (BP) with neuropsychiatric diseases is well\u2010established, the clinical and immunological profile of BP patients with this comorbidity remains to be decisively determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the burden of neurological and psychiatric comorbidities among patients with BP and to elucidate the clinical, immunological and immunopathological features of patients with BP and comorbid neuropsychiatric conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective study encompassing patients diagnosed with BP throughout the years 2009\u20132020 in a specialized tertiary referral centre. Multivariate logistic regression model was used to identify predictors of neuropsychiatric conditions among patients with BP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 273 patients with BP, of whom 123 (45.1%) presented with comorbid neuropsychiatric disease. Compared to the remaining patients with BP (<jats:italic>n<\/jats:italic>\u00a0=\u00a0150), those with pre\u2010existing neuropsychiatric diseases demonstrated older mean [standard deviation (SD)] age [81.7 (9.1) vs. 76.9 (10.1); <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001], female preponderance (65.0% vs. 49.3%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009), higher seropositivity rate of anti\u2010BP230 (67.7% vs. 36.5%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) and higher levels of anti\u2010BP180 NC16A IgG [651.3 (1279.6) vs. 370.4 (818.6) U\/mL; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.039]. In multivariate analysis, anti\u2010BP230 seropositivity was independently associated with coexistence of BP with neuropsychiatric conditions [adjusted odds ratio (OR), 3.43; 95% CI, 1.24\u20139.52; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.018]. In a sensitivity analysis confined to patients with neurological diseases (<jats:italic>n<\/jats:italic>\u00a0=\u00a0103), older age [82.1 (8.4) vs. 77.2 (10.3); <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001] and increased anti\u2010BP230 seropositivity (68.0% vs. 39.7%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.018) were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The coexistence of BP with neuropsychiatric diseases is independently associated with the generation of anti\u2010BP230 antibodies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17304","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T13:18:54Z","timestamp":1619356734000},"page":"2067-2073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Coexistence of bullous pemphigoid with neuropsychiatric comorbidities is associated with anti\u2010BP230 seropositivity"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0183-0375","authenticated-orcid":false,"given":"S.","family":"St\u00e4nder","sequence":"first","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.M.","family":"Hammers","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"},{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Vorobyev","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1206-8913","authenticated-orcid":false,"given":"E.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"},{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.E.","family":"Hundt","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6701-048X","authenticated-orcid":false,"given":"C.D.","family":"Sadik","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck 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