{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:46:18Z","timestamp":1790520378552,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T00:00:00Z","timestamp":1621123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In a European study on contact allergy in the general population, it has been hypothesized that the combination of contact allergy to a fragrance together with a history indicating dermatitis at exposure and thereafter subsequent avoidance of scented products implied a diagnosis of allergic contact dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The primary aim of this study was to validate this hypothesis\/algorithm. The secondary aim was to investigate whether there was any association between the outcome of the recent repeated open application test (ROAT) and the patch test reactivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred nine subjects with and without contact allergy to fragrance mix II (FM II) were recruited. Volunteers from six European dermatology clinics participated in the study including a patch test and a ROAT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four positive ROAT reactions were noted in total including 20 of those 32 with contact allergy to FM II. None of the volunteers reacted to the vehicle (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). More individuals with a positive algorithm had positive ROATs when compared with those with a negative algorithm. However, the difference was not statistically significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.12). The lower the patch test concentration eliciting a positive test reaction, the more likely was a positive ROAT and the more likely that the positive ROAT appeared early during the investigative period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The algorithm used in this study was not validated but it was indicated in this ROAT setup. The stronger the patch test reactivity the more likely was a positive ROAT and the more likely it was that the positive ROAT appeared early during the application period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17315","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T17:18:52Z","timestamp":1619716732000},"page":"1692-1701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Validation of questionnaire algorithm based on repeated open application testing with the constituents of fragrance mix II: the EDEN Fragrance Study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-3227","authenticated-orcid":false,"given":"M.","family":"Bruze","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Engfeldt","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7696-3274","authenticated-orcid":false,"given":"P.","family":"Elsner","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Jena Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gon\u00e7alo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital and Faculty of Medicine University of Coimbra Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Naldi","sequence":"additional","affiliation":[{"name":"Centro Studi GISED \u2013 FROM Presidio Ospedaliero Matteo Rota Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.L.A.","family":"Schuttelaar","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4797-0269","authenticated-orcid":false,"given":"C.","family":"Svedman","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2821-7418","authenticated-orcid":false,"given":"\u00c5.","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Lund University Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ofenloch","sequence":"additional","affiliation":[{"name":"Occupational Dermatology Department of Dermatology University Hospital Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1990.tb05003.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319757"},{"key":"e_1_2_6_4_1","first-page":"154","article-title":"EDEN Fragrance Study Group. 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