{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T11:45:42Z","timestamp":1750938342725,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Maculopapular cutaneous mastocytosis (MPCM) in children is classified in two variants: (i) monomorphic variant, presenting with the small macules or papules typically seen in adult patients; and (ii) polymorphic variant with larger lesions of variable size and shape, typically seen in children. The definition of polymorphic and monomorphic variants is mostly intuitive, and a validation of this classification has not been done.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study interobserver variability in the classification of MPCM in two groups of observers: mastocytosis experts and general dermatologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Nineteen cases of childhood MPCM were shown blindly, for classification as monomorphic or polymorphic type, to 10 independent observers (eight dermatologists, one allergist and one haematologist) from Europe and North America with a vast experience in the management of paediatric mastocytosis. Also, the same cases were shown on a screen to 129 general dermatologists attending a meeting; their votes were registered by remote controls. The interobserver variability kappa coefficient (with 95% confidence interval) was calculated to measure the reliability of the correlation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The value of kappa interobserver variability coefficient for the group of 10 experts (95% confidence interval) was 0.39 (0.18\u20130.63), which is considered as \u2018fair\u2019. The value of kappa interobserver variability coefficient for the group of 129 general dermatologists (95% confidence interval) was 0.17 (0.06\u20130.39), which is considered as \u2018slight\u2019. A complete agreement of all 10 experts was achieved in only four of 19 cases (21.1%) The most voted choice was concordant between the two groups in only 11 of the 19 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We failed to validate the classification system of childhood MPCM in monomorphic and polymorphic types. While the rate of agreement was low for mastocytosis experts, it was nearly the agreement expected by chance in general dermatologists.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17345","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T13:06:37Z","timestamp":1620997597000},"page":"2079-2084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Interobserver variability in the classification of childhood maculopapular cutaneous mastocytosis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5940-6916","authenticated-orcid":false,"given":"A.","family":"Torrelo","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8646-3636","authenticated-orcid":false,"given":"L.","family":"Vergara\u2010de\u2010la\u2010Campa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Toledo Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6736-7697","authenticated-orcid":false,"given":"J.M.","family":"Aza\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Hospitalario Universtario de Albacete Albacete Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Greenberger","sequence":"additional","affiliation":[{"name":"Pediatric Dermatology Service Department of Dermatology Sheba Medical Center Tel\u2010Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Department of Dermatology and Skin Science University of British Columbia Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.P.","family":"Lawley","sequence":"additional","affiliation":[{"name":"Department of Dermatology Emory University Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.\u2010A.","family":"Morren","sequence":"additional","affiliation":[{"name":"Pediatric Dermatology Unit Department of Pediatrics and Dermatology &amp;Venereology University hospital Lausanne and University of Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.V.","family":"Schaffer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology Hackensack Meridian School of Medicine Hackensack NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Garc\u00eda\u2010Doval","sequence":"additional","affiliation":[{"name":"Research Unit Fundaci\u00f3n Piel Sana AEDV Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Matito","sequence":"additional","affiliation":[{"name":"Instituto de Estudios de Mastocitosis de Castilla La Mancha (CLMast) \u2013 Spanish Reference Center for Mastocytosis Hospital Virgen del Valle Complejo Hospitalario Universitario de Toledo Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1190-4473","authenticated-orcid":false,"given":"I.","family":"Alvarez\u2010Twose","sequence":"additional","affiliation":[{"name":"Instituto de Estudios de Mastocitosis de Castilla La Mancha (CLMast) \u2013 Spanish Reference Center for Mastocytosis Hospital Virgen del Valle Complejo Hospitalario Universitario de Toledo Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15624"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2018.04.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.08.034"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.05.034"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2012.29534"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328355b248"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(01)00044-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.98"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13850"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573396315666181120163952"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14492"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.08.035"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-020-00581-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529786"}],"container-title":["Journal 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