{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:05:56Z","timestamp":1791497156182,"version":"4.3.4"},"reference-count":76,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006484","name":"AbbVie Deutschland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with chronic skin diseases suffer from physical and psychosocial impairments which can lead to a cumulative life\u2010long burden. Therefore, the concept of cumulative life course impairment (CLCI) was introduced, referring to the non\u2010reversible damage due to the persistent life\u2010long burden. This systematic review (PROSPERO registry number: CRD42020179141) aimed at mapping the risk factors and the associated burden over time in patients with psoriasis, atopic dermatitis (AD) and hidradenitis suppurativa (HS). Three electronic databases were searched (date of the last search: December 2019). Studies with a longitudinal study design that assessed the association between a risk factor and the associated burden over time in patients with psoriasis, AD and HS were included. Quality assessment of the included studies was done using Critical Appraisal Skills Programme (CASP) checklists. In total, 40 publications reflecting 25 different studies were included: nine studies addressed patients with psoriasis, 13 patients with AD, two studies included patients with HS and one study enrolled patients with psoriasis and AD, respectively. Twenty\u2010two potential risk factors with underlying evidence were found in this review. These risk factors include mainly sociodemographic (such as age or gender) and clinical (such as disease severity or comorbidities) variables. Disease severity and comorbidities were the most often studied risk factors, while only a few studies evaluated psychosocial risk factors over time. Patients with chronic skin diseases are at high risk to develop a life\u2010long negative impact from the disease. However, there is a lack of data that evaluates the psychosocial burden and its influence on the patients\u2019 life course over time. The risk factors found in this review help to identify patients at risk, to treat them adequately and, ultimately, to prevent CLCI. These results can be the basis to develop a highly needed tool to assess the risk for CLCI in the future.<\/jats:p>","DOI":"10.1111\/jdv.17348","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T13:06:14Z","timestamp":1620997574000},"page":"2166-2184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Mapping risk factors for cumulative life course impairment in patients with chronic skin diseases \u2013 a systematic review"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6269-5125","authenticated-orcid":false,"given":"C.C.","family":"von St\u00fclpnagel","sequence":"first","affiliation":[{"name":"German Center for Health Services Research in Dermatology (CVderm) Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4026-8728","authenticated-orcid":false,"given":"M.","family":"Augustin","sequence":"additional","affiliation":[{"name":"German Center for Health Services Research in Dermatology (CVderm) Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"D\u00fcpmann","sequence":"additional","affiliation":[{"name":"German Center for Health Services Research in Dermatology (CVderm) Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4110-9961","authenticated-orcid":false,"given":"N.","family":"da Silva","sequence":"additional","affiliation":[{"name":"German Center for Health Services Research in Dermatology (CVderm) Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3080-497X","authenticated-orcid":false,"given":"R.","family":"Sommer","sequence":"additional","affiliation":[{"name":"German Center for Health Services Research in Dermatology (CVderm) Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000313825"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.122755"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1044492"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07916.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2004.00078.x"},{"key":"e_1_2_7_7_1","first-page":"93","article-title":"Atopic dermatitis and psychosocial comorbidities","volume":"18","author":"Kage P","year":"2020","journal-title":"Journal der Deutschen Dermatologischen Gesellschaft"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13541"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200506060-00005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16255"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1193"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000084751"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-019-4411-y"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13841"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08068.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.530"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03705.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/31.2.285"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.soc.34.040507.134619"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.26.021304.144505"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350555"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1252022"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/21556660.2019.1619570"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2014.07.012"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S111019"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000111512"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350008"},{"key":"e_1_2_7_28_1","first-page":"45","article-title":"The importance of mental support to the patients with adult atopic dermatitis","volume":"42","author":"Shirata K","year":"1996","journal-title":"Osaka City Med J"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i39.7198"},{"key":"e_1_2_7_32_1","volume-title":"CRD\u2019s guidance for undertaking reviews in healthcare","author":"Centre for Reviews and Dissemination","year":"2009"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201002300128"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03469.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17208"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2183"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.186"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.08.039"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2010.02310.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr285"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.113"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.87"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.14.1735"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15052"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12742"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.09.004"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.613"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.06.013"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-12-168"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-12-11"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.055"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448515"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.06.020"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1037\/hea0000404"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S180036"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2457"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.3109\/09638288.2011.553704"},{"key":"e_1_2_7_58_1","volume-title":"WHO Framework on integrated people\u2010centred health services [WWW document]","author":"World Health Organization","year":"2020"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2015.350"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2912"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2330"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2002.00495.x"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.02767.x"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15616"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-015-0117-9"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39494"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099609"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00391.x"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12619"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.09.044"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1177\/1359105316660181"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02487.x"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.06.029"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.399"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700229"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.08.036"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171667"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.17348","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.17348","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.17348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T14:26:55Z","timestamp":1692455215000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.17348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,25]]},"references-count":76,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/jdv.17348"],"URL":"https:\/\/doi.org\/10.1111\/jdv.17348","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,25]]},"assertion":[{"value":"2021-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}