{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:57:50Z","timestamp":1760029070264,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Due to a large variety in treatment outcomes reported in therapeutic trials and lacking patient\u2010relevant outcomes, it is hard to adequately compare and improve current therapies for patients with capillary malformations (CMs). The Core Outcome Set for Capillary Malformations (COSCAM) project aims to develop a core outcome set (COS) for use in future CM trials, in which we will first develop a core outcome (sub)domain set (CDS). Here, we describe the methods for the development of a CDS and present the results of the first development stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The COSCAM project is carried out according to the recommendations of the Cochrane Skin Core OUtcomes Set INitiative (CS\u2010COUSIN) and the Core Outcome Measures in Effectiveness Trials (COMET) initiative. During the first stage, we identified all potentially relevant outcome subdomains based on a systematic review, two focus group sessions and input from patient representatives of Dutch patient organizations and the COSCAM\u2010founding group. In stage two, we will present the subdomains in a three\u2010round e\u2010Delphi study and online consensus meeting, in which CM patients, parents\/caregivers and CM experts worldwide rate the importance of the proposed subdomains, hereby finalizing the core outcome (sub)domains of the CDS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 67 potential outcome subdomains were included; sixteen were previously used in the literature, 20 were proposed by Dutch patients and their parents\/caregivers (<jats:italic>n<\/jats:italic>\u00a0=\u00a013) in focus group sessions and 38 were suggested by the experts of the COSCAM\u2010founding group. Seven were excluded because of overlap.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The final CDS may serve as a minimum standard in future CM trials, thereby facilitating adequate comparison of treatment outcomes. After this CDS development, we will select appropriate outcome measurement instruments to measure the core outcome subdomains.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17376","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T13:58:16Z","timestamp":1621519096000},"page":"1888-1895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Development of a core outcome domain set for clinical research on capillary malformations (the COSCAM project)"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9801-1415","authenticated-orcid":false,"given":"G.B.","family":"Langbroek","sequence":"first","affiliation":[{"name":"Department of Surgery Amsterdam University Medical Center (UMC) Location AMC University of Amsterdam Amsterdam 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Maastricht University Medical Center Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0684-4322","authenticated-orcid":false,"given":"F.","family":"Al\u2010Niaimi","sequence":"additional","affiliation":[{"name":"Private Dermatological Practice London UK"},{"name":"Department of Dermatology University of Aalborg Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Tokai University School of Medicine Shimokasuya Isehara Kanagawa Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9136-9019","authenticated-orcid":false,"given":"P.","family":"Boixeda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Ramon y Cajal Madrid 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