{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:53:36Z","timestamp":1781657616323,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with mycosis fungoides (MF) are at increased risk of developing non\u2010Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), lung cancer, bladder cancer and melanoma. The characteristics of patients developing these malignancies have not been specifically delineated. In addition, there are no established guidelines for screening MF patients for second malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials\/Methods<\/jats:title><jats:p>We identified 742 patients with MF who developed second malignancies in the Surveillance Epidemiology and End Result\u201018 database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The majority of second malignancy patients were white and male, mean age 55\u201367\u00a0years at diagnosis of MF, and mean age 61\u201372\u00a0years at diagnosis of second malignancy. The majority of patients diagnosed with second malignancies had early stage MF. MF patients with NHL, lung cancer, and bladder cancer tended to be diagnosed at earlier stages of the second malignancy than patients without MF and demonstrated better 5\u2010year overall survival. There was no improvement in stage at diagnosis or survival for MF patients who were diagnosed with melanoma compared to patients without MF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Improvements in survival in MF\/NHL, MF\/lung cancer and MF\/bladder cancer patients may reflect differences in disease biology secondary to having MF or the importance of increased contact with the healthcare system. MF\/melanoma data suggest that patients require regular pigmented\u2010lesion\u2010focused skin examinations. Tools for screening include regular lymph node examinations, pigmented\u2010lesion\u2010focused examinations and detailed review of systems questions. Smoking cessation counseling is key intervention in this population, as is ensuring that all age\u2010 and sex\u2010specific cancer screenings are up\u2010to\u2010date (e.g. lung cancer screening, mammography, and colonoscopy). The utility of regular imaging for second malignancy screening and lab testing such as routine urinalysis requires additional study and expert consensus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17384","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T08:44:24Z","timestamp":1621500264000},"page":"1821-1829","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Screening for second malignancies in mycosis fungoides: non\u2010Hodgkin lymphoma, Hodgkin lymphoma, lung cancer, bladder cancer and melanoma"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3790-8242","authenticated-orcid":false,"given":"A.","family":"Goyal","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Minnesota Minneapolis MN 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