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PPE is associated with several side events, including skin reactions. The objective of this study was to summarize the prevalence, type and risk factors for cutaneous adverse events related to PPE and prevention measures to avoid them. A systematic review and meta\u2010analysis was conducted using MEDLINE, Scopus and EMBASE databases from conception to 21 January 2021. All types of epidemiological studies regarding skin adverse events related to PPE were included. The literature search identified 1007 references, 35 of them met the eligible criteria and were included for analysis, representing 31\u00a0453 participants. The media of skin side events related to PPE was 75.13%. The rate of cutaneous adverse events related to mask was 57.71%, and those associated with gloves and hand hygiene products was 49.16%. Most common skin adverse events were contact dermatitis, acne and itching. The most damaged anatomical regions were the nasal bridge, the cheeks and the hands. The duration of PPE wearing was the most common risk factor. Frequent handwashing, gloves and masks were the agents most frequently related to skin reactions. N95 respirators were the most harmful mask type for the skin. Hydrocolloid use prevented from developing skin adverse events related to masks. In conclusion, the rate of cutaneous adverse events related to PPE use is high. A longer duration of PPE wearing was the most common risk factor. Using hydrocolloid could prevent from skin injuries related to mask use.<\/jats:p>","DOI":"10.1111\/jdv.17436","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T21:38:20Z","timestamp":1622669900000},"page":"1994-2006","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Skin adverse events related to personal protective equipment: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4035-7955","authenticated-orcid":false,"given":"T.","family":"Montero\u2010Vilchez","sequence":"first","affiliation":[{"name":"Department of Dermatology Virgen de las Nieves University Hospital Granada Spain"},{"name":"Biosanitary Institute of Granada (ibs.GRANADA) Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7579-4931","authenticated-orcid":false,"given":"C.","family":"Cuenca\u2010Barrales","sequence":"additional","affiliation":[{"name":"Department of Dermatology Virgen de las Nieves University Hospital Granada Spain"},{"name":"Biosanitary Institute of Granada (ibs.GRANADA) Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0304-7317","authenticated-orcid":false,"given":"A.","family":"Martinez\u2010Lopez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Virgen de las Nieves University Hospital Granada Spain"},{"name":"Biosanitary Institute of Granada (ibs.GRANADA) Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6882-2113","authenticated-orcid":false,"given":"A.","family":"Molina\u2010Leyva","sequence":"additional","affiliation":[{"name":"Department of Dermatology Virgen de las Nieves University Hospital Granada Spain"},{"name":"Biosanitary Institute of Granada (ibs.GRANADA) Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4186-1435","authenticated-orcid":false,"given":"S.","family":"Arias\u2010Santiago","sequence":"additional","affiliation":[{"name":"Department of Dermatology Virgen de las Nieves University Hospital Granada Spain"},{"name":"Biosanitary Institute of Granada (ibs.GRANADA) Granada Spain"},{"name":"Cell Production and Tissue Engineering Unit Virgen de las Nieves University Hospital Andalusian Network of Design and Translation of Advanced Therapies Granada Spain"},{"name":"Department of Dermatology Faculty of Medicine University of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Johns Hopkins University and Medicine.Coronavirus Resource Center 2020. 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