{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:50:32Z","timestamp":1761101432594,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T00:00:00Z","timestamp":1625270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic sun damage in the background is common in pigmented actinic keratoses and Bowen\u2019s disease (pAK\/BD). While explainable artificial intelligence (AI) demonstrated increased background attention for pAK\/BD, humans frequently miss this clue in dermatoscopic images because they tend to focus on the lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To analyse whether perilesional sun damage is a robust diagnostic clue for pAK\/BD and if teaching this clue to dermatoscopy users improves their diagnostic accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed the interrater agreement and the frequency of perilesional sun damage in 220 dermatoscopic images and conducted a reader study with 124 dermatoscopy users. The readers were randomly assigned to one of two online tutorials; one tutorial pointed to perilesional sun damage as a clue to pAK\/BD (group A) the other did not (group B). In both groups, we compared the frequencies of correct diagnoses before and after receiving the tutorial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of perilesional sun damage was higher in pAK\/BD than in other types of pigmented skin lesions and interrater agreement was good (kappa\u00a0=\u00a00.675). The diagnostic accuracy for pAK\/BD improved in both groups of readers (group A: +16.1%, 95%\u2010CI: 9.5\u201322.7; group B: +13.1%; 95%\u2010CI: 7.1\u201319.0; <jats:italic>P<\/jats:italic> for both &lt;0.001), but the overall accuracy improved only in group A from (59.1% (95%\u2010CI: 55.0\u201363.1) to 63.5% (95%\u2010CI: 59.5\u201367.6); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Perilesional sun damage is a good clue to differentiate pAK\/BD from other pigmented skin lesions in dermatoscopic images, which could be useful for teledermatology. Knowledge of this clue improves the accuracy of dermatoscopy users, which demonstrates that insights from explainable AI can be used to train humans.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17464","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T15:58:05Z","timestamp":1624118285000},"page":"2022-2026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Perilesional sun damage as a diagnostic clue for pigmented actinic keratosis and Bowen\u2019s disease"],"prefix":"10.1111","volume":"35","author":[{"given":"P.","family":"Weber","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5589-1865","authenticated-orcid":false,"given":"C.","family":"Sinz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3847-5664","authenticated-orcid":false,"given":"C.","family":"Rinner","sequence":"additional","affiliation":[{"name":"Center for Medical Statistics, Informatics and Intelligent Systems Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0051-8016","authenticated-orcid":false,"given":"H.","family":"Kittler","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0391-7810","authenticated-orcid":false,"given":"P.","family":"Tschandl","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/ddg.14220","article-title":"Dermatoscopic features of pigmented intraepidermal carcinoma on the head and neck","volume":"18","author":"Inskip M","year":"2020","journal-title":"JDDG. 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