{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:24:29Z","timestamp":1789759469259,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Apart from bullous pemphigoid (BP), the association of other autoimmune bullous diseases (AIBDs) with neurological conditions is poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate the association between a wide array of AIBDs and neurological conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cross\u2010sectional study recruited patients with BP, mucous membrane pemphigoid (MMP), epidermolysis bullosa acquisita (EBA), pemphigoid gestationis (PG), pemphigus vulgaris (PV) and pemphigus foliaceus (PF). These patients were compared with their age\u2010 and sex\u2010matched control subjects with regard to the lifetime prevalence of Parkinson's disease (PD), Alzheimer's disease (AD), stroke, epilepsy and multiple sclerosis (MS). Logistic regression was used to calculate OR for specified neurological disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The current study included 1743, 251, 106, 126, 860 and 103 patients diagnosed with BP, MMP, EBA, PG, PV and PF, respectively. These patients were compared with 10\u00a0141, 1386, 606, 933, 5142 and 588 matched controls, respectively. Out of the investigated neurological conditions, PD associated with BP (OR, 2.71; 95% CI, 2.19\u20133.35); AD with BP (OR, 2.11; 95% CI, 1.73\u20132.57), MMP (OR, 2.37; 95% CI, 1.03\u20135.47), EBA (OR, 6.00; 95% CI, 1.90\u201318.97) and PV (OR, 2.24; 95% CI, 1.40\u20133.60); stroke with BP (OR, 1.84; 95% CI, 1.55\u20132.19) and EBA (OR, 2.79; 95% CI, 1.11\u20137.01); and epilepsy with BP (OR, 2.18; 95% CI, 1.72\u20132.77) and PV (OR, 1.80; 95% CI, 1.19\u20132.73). MS did not significantly cluster with any of the six AIBDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In addition to BP, EBA and PV were found to cluster with neurological comorbidities. Patients with these AIBDs with compatible symptoms may be carefully assessed for comorbid neurological disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17465","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T01:07:44Z","timestamp":1624324064000},"page":"2074-2078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The burden of neurological comorbidities in six autoimmune bullous diseases: a population\u2010based study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9971-9151","authenticated-orcid":false,"given":"K.","family":"Kridin","sequence":"first","affiliation":[{"name":"L\u0171beck Institute of Experimental Dermatology University of L\u00fcbeck L\u00fcbeck Germany"},{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University Safed Israel"},{"name":"Unit of Dermatology and Skin Research Laboratory Baruch Padeh Poria Medical Center Tiberias Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2886-9499","authenticated-orcid":false,"given":"F.","family":"H\u00fcbner","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Recke","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Linder","sequence":"additional","affiliation":[{"name":"Techniker Krankenkasse, Corporate Development Analytics and Insights Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1206-8913","authenticated-orcid":false,"given":"E.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"L\u0171beck Institute of Experimental Dermatology University of L\u00fcbeck L\u00fcbeck Germany"},{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31778-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61140-4"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13637_g"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2611"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14503"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18731"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.5240"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13660"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.322"},{"key":"e_1_2_5_11_1","article-title":"Neurological diseases and bullous pemphigoid: a case\u2010control study in Iranian patients","volume":"83","author":"Daneshpazhooh M","year":"2017","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.357"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12995"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15444"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13401"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.5799"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.72.2.259"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-039747"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.09.010"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530318666180731115226"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17882"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-018-0896-1"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00192642"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.5772\/62527"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.05.109"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2003.120103.x"},{"key":"e_1_2_5_28_1","first-page":"833","article-title":"S2k\u2010Leitlinie zur therapie des pemphigus vulgaris\/foliaceus und des bull\u00f6sen pemphigoid","volume":"13","author":"Eming R","year":"2015","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-7622-2-11"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.17465","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.17465","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.17465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T13:25:18Z","timestamp":1693315518000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.17465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,4]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/jdv.17465"],"URL":"https:\/\/doi.org\/10.1111\/jdv.17465","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,4]]},"assertion":[{"value":"2021-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}