{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:00:55Z","timestamp":1791896455847,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The distinction between epidermal necrolysis [EN; including Stevens\u2013Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and overlap syndrome] and erythema multiforme major (EMM) in children is confusing. We aimed to better describe and compare these entities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This French retrospective multicentre study included children \u226418\u00a0years old referred for EN or EMM between 1 January 2008 and 1 March 2019. According to pictures, children were reclassified into TEN\/overlap, SJS or EMM\/unclassified (SJS\/EMM) groups and compared for epidemiological and clinical data, triggers, histology and follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 62 children [43 boys, median age 10\u00a0years (range 3\u201318)]: 16 with TEN\/overlap, 11 SJS and 35 EMM. The main aetiologies were drugs in EN and infections (especially <jats:italic>Mycoplasma pneumoniae<\/jats:italic>) in EMM (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), but 35% of cases remained idiopathic (TEN\/overlap, 47%; SJS, 24%; EMM, 34%). The typical target lesions predominated in EMM (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), the trunk was more often affected in EN (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and the body surface area involved was more extensive in EN (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Mucosal involvement did not differ between the groups. Two patients with idiopathic TEN died. Histology of EMM and EN showed similar features. The recurrence rate was 42% with EMM, 7% with TEN\/overlap and 0 with SJS (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Sequelae occurred in 75% of EN but involved 55% of EMM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinical features of EN and EMM appeared well demarcated, with few overlapping cases. Idiopathic forms were frequent, especially for EN, meaning that a wide and thorough infectious screening, repeated if needed, is indicated for all paediatric cases of EN\/EMM without any trigger drug. We propose a comprehensive panel of investigations which could be a standard work\u2010up in such situation. Sequelae affected both EN and EMM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17469","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T18:46:44Z","timestamp":1624387604000},"page":"2051-2058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Childhood epidermal necrolysis and erythema multiforme major: a multicentre French cohort study of 62 patients"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6009-3814","authenticated-orcid":false,"given":"L.","family":"Giraud\u2010Kerleroux","sequence":"first","affiliation":[{"name":"Dermatology Department AP\u2010HP CHU Necker\u2010Enfants Malades Paris Centre University Paris France"},{"name":"Dermatology Department AP\u2010HP CHU Henri Mondor Cr\u00e9teil 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