{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:35:18Z","timestamp":1783427718988,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hidradenitis suppurativa (HS), a chronic, recurrent, debilitating skin disease, is characterized by painful, inflammatory, subcutaneous lesions of the axilla, inguinal and anogenital regions. Overall prevalence of HS is \u02dc1%, and the impact of disease on patient quality of life (QoL) and healthcare resource utilization (HRU) is high.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To estimate the real\u2010world effectiveness of adalimumab (Humira\u00ae) treatment in patients with moderate\u2010to\u2010severe HS on disease severity, pain, QoL, work productivity and HRU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HARMONY (Effectiveness of Adalimumab in Moderate to Severe HidrAdenitis SuppuRativa Patients \u2013 a Multi\u2010cOuNtry studY in Real Life Setting) is a multicentre, postmarketing observational study in adult patients with moderate\u2010to\u2010severe HS. Disease severity and QoL parameters were evaluated using validated measures at 12\u2010week intervals over 52\u00a0weeks of treatment. The primary endpoint was the proportion of patients achieving a Hidradenitis Suppurativa Clinical Response (HiSCR: \u226550% reduction in abscess and inflammatory nodule count, with no increase in abscess and draining fistula counts relative to baseline) at 12\u00a0weeks. Secondary endpoints were HiSCR at 24, 36 and 52\u00a0weeks and changes in QoL parameters and work productivity assessments. Analyses were conducted using as\u2010observed data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of patients reaching the primary HiSCR endpoint was 70.2% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0132\/188 enrolled) and remained \u226570% until study completion. There were statistically significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) reductions in worst and average skin pain. All of the QoL measures evaluated improved significantly (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) by 12\u00a0weeks of adalimumab treatment, as did work productivity assessments (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), and there was a \u02dc50% decrease in HRU between baseline and week 52. Adalimumab was well tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this real\u2010world setting, adalimumab treatment of moderate\u2010to\u2010severe HS resulted in decreased disease severity and improvements in QoL and productivity. Response to adalimumab was rapid (within 12\u00a0weeks) and sustained (52\u00a0weeks). No unexpected safety signals were reported.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17551","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T16:30:41Z","timestamp":1627489841000},"page":"2277-2284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Improvement in Hidradenitis Suppurativa and quality of life in patients treated with adalimumab: Real\u2010world results from the HARMONY Study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2400-3922","authenticated-orcid":false,"given":"A.","family":"Hafner","sequence":"first","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.D.","family":"Ghislain","sequence":"additional","affiliation":[{"name":"UCL St Luc Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University of Szeged Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Batchelor","sequence":"additional","affiliation":[{"name":"Royal Devon and Exeter NHS Foundation Trust Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8189-7486","authenticated-orcid":false,"given":"A.C.","family":"Katoulis","sequence":"additional","affiliation":[{"name":"Second Department of Dermatology and Venereology National and Kapodistrian University of Athens Medical School \u2018Attikon\u2019 General University Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kirby","sequence":"additional","affiliation":[{"name":"Department of Dermatology St Vincent\u2019s University Hospital and University College Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Banayan","sequence":"additional","affiliation":[{"name":"AbbVie Biopharmaceuticals Ltd Hod Hasharon Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schonbrun","sequence":"additional","affiliation":[{"name":"AbbVie Biopharmaceuticals Ltd Hod Hasharon Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f2121"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.08.090"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12966"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.11.911"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41702-019-0052-0"},{"key":"e_1_2_7_7_1","first-page":"17","article-title":"Hidradenitis suppurativa: causes, features, and current treatments","volume":"11","author":"Vinkel C","year":"2018","journal-title":"J Clin Aesthet 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