{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:17:06Z","timestamp":1790295426980,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Syphilis is a sexually transmitted infection (STI) with a global prevalence estimated at 0.5% in 2012. Syphilis has been on the rise among men who have sex with men (MSM) in high\u2010income countries and remains at endemic levels in low\u2010 and middle\u2010income countries. This trend, however, has not been observed in Reunion Island.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the prevalence, clinical characteristics and risk factors of syphilis in at\u2010risk patients visiting the South Reunion STI clinic in Reunion Island.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This monocentric cross\u2010sectional study included all patients who visited our STI clinic between 2017 and 2020. Syphilis serology was performed on all included patients, and data were collected using a standardized self\u2010administered questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over the 3\u2010year study period, 2593 patients were enrolled. The prevalence of syphilis was 7.52% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0195, 95% CI, 6.50\u20138.65%) in the overall study population, 11.76% (<jats:italic>n<\/jats:italic>\u00a0=\u00a018, 95% CI, 6.97\u201318.59%) in minors (aged under 18\u00a0years) and 36.36% (<jats:italic>n<\/jats:italic>\u00a0=\u00a016, 95% CI, 21\u201359%) in pregnant women. The risk factors identified in multivariate analysis were being female [adjusted Prevalence Ratio (aPR) 1.85, 95% CI, 1.10\u20133.11], being MSM (aPR 2.87, 95% CI, 1.71\u20134.80), being aged under 18\u00a0years (aPR 3.54, 95% CI, 1.90\u20136.57), living in precarious conditions [aPR 3.12, 95% CI, 2.11\u20134.62] and being born in Reunion Island (aPR 2.43, 95% CI, 1.42\u20134.13). The clinical presentation was heterogeneous (plaques and papules, chancre, atypical ulcerations, multiple ulcerations, condyloma lata, etc.).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest a high prevalence of syphilis in at\u2010risk patients visiting our STI clinic. Unlike the situation in other high\u2010income countries, the people most at risk of syphilis in Reunion Island are local\u2010born residents, minors, women and precarious patients. This is a source of concern, especially given the risk of resurgence of congenital syphilis on the island.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17572","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T18:13:19Z","timestamp":1627755199000},"page":"2287-2292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["High prevalence of syphilis in women, minors and precarious patients: a cross\u2010sectional study in a Reunion Island sexually transmitted infection clinic, 2017\u20132020"],"prefix":"10.1111","volume":"35","author":[{"given":"A.","family":"Delfosse","sequence":"first","affiliation":[{"name":"Service des Maladies Infectieuses \u2010 Dermatologie CHU Re\u0301union Saint Pierre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Bouscaren","sequence":"additional","affiliation":[{"name":"Inserm CIC1410 CHU Re\u0301union Saint Pierre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Dupin","sequence":"additional","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Cochin AP\u2013HP CNR de la syphilis Institut Cochin U1016 Universite\u0301 Paris Descartes Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Jaubert","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie CHU Re\u0301union Saint Pierre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.L.","family":"Tran","sequence":"additional","affiliation":[{"name":"Service de Gyne\u0301cologie Obste\u0301trique CHU Re\u0301union Saint Pierre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Saint Pastou","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses \u2010 Dermatologie CHU Re\u0301union Saint Pierre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Manaquin","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses \u2010 Dermatologie CHU Re\u0301union Saint Pierre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Poubeau","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses \u2010 Dermatologie CHU Re\u0301union Saint Pierre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Gerardin","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses \u2010 Dermatologie CHU Re\u0301union Saint Pierre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3962-8869","authenticated-orcid":false,"given":"A.","family":"Bertolotti","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses \u2010 Dermatologie CHU Re\u0301union Saint Pierre France"},{"name":"Inserm CIC1410 CHU Re\u0301union Saint Pierre France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143304"},{"key":"e_1_2_8_3_1","unstructured":"World Health Organization.Global Health Sector Strategy on Sexually Transmitted Infections 2016\u20102021. 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