{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:02:53Z","timestamp":1788998573296,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005722","name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","doi-asserted-by":"publisher","award":["F\u00f6FoLe 1022"],"award-info":[{"award-number":["F\u00f6FoLe 1022"]}],"id":[{"id":"10.13039\/501100005722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The treatment of keratinocyte cancers (KC) strictly depends on their differentiation and invasiveness. Non\u2010invasive diagnostic techniques can support the diagnosis in real time, avoiding unnecessary biopsies. This study aimed to preliminarily define main imaging criteria and histological correlations of actinic keratosis (AK), Bowen\u2019s disease (BD) and squamous cell carcinoma (SCC) using the novel device line\u2010field confocal optical coherence tomography (LC\u2010OCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Dermoscopy and LC\u2010OCT images of 73 histopathologically confirmed lesions (46 AKs, 11 BD and 16 SCCs) were included in the study. Exemplary lesions (10 AKs, 5 BD and 5 SCCs) were additionally investigated with optical coherence tomography and reflectance confocal microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most common LC\u2010OCT findings of KC in the descriptive statistics were hyperkeratosis\/parakeratosis, disruption of stratum corneum, broadened epidermis, basal and suprabasal keratinocyte atypia, dilated vessels\/neoangiogenesis and elastosis\/collagen alterations. In the univariate multinomial logistic regression, a preserved DEJ was less common in SCC compared with AK and BD, BD displayed marked keratinocyte atypia involving all epidermal layers (bowenoid pattern), while SCC showed ulceration, increased epidermal thickness, keratin plugs, acantholysis, not visible\/interrupted DEJ and epidermal bright particles. LC\u2010OCT increased the diagnostic confidence by 24.7% compared with dermoscopy alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study describes for the first time specific LC\u2010OCT features of different stages of KC and their histopathological correlates, focusing on keratinocyte morphology and architecture of the epidermis and DEJ. LC\u2010OCT may open new scenarios in the bedside diagnosis, treatment planning and follow\u2010up of KC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.17603","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T09:08:31Z","timestamp":1629450511000},"page":"2388-2397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Line\u2010field confocal optical coherence tomography for the in\u2009vivo real\u2010time diagnosis of different stages of keratinocyte skin cancer: a preliminary study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-1095","authenticated-orcid":false,"given":"C.","family":"Ruini","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital LMU Munich Germany"},{"name":"PhD School in Clinical and Experimental Medicine University of Modena and Reggio Emilia Modena 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