{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:41:03Z","timestamp":1763037663226,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Growing evidence indicates that amoxicillin induces herpesvirus replication <jats:italic>in\u2009vitro<\/jats:italic>. As these play a central pathophysiological role in Drug Reaction with Eosinophilia and Systemic Symptoms syndrome (DRESS), amoxicillin could present with specific DRESS features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize the onset patterns of amoxicillin\u2010associated DRESS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All cases of DRESS (Kardaun score \u22654) involving amoxicillin and reported in the French Pharmacovigilance Database between January 1, 2004 and November 30, 2019 were included. Onset circumstances for these cases were categorized considering the onset delay from amoxicillin initiation, and the presence of concomitant medications with a compatible time to onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 146 probable cases or definite cases of DRESS were included. Three onset circumstances were identified: (i) \u2018amoxicillin clear culprit\u2019 where amoxicillin was the sole suspect drug or when concomitant drugs of compatible time to onset were not reported to cause DRESS (<jats:italic>n<\/jats:italic>\u2009=\u200962); (ii) \u2018amoxicillin possible culprit\u2019 in the presence of other potentially culprit drugs in addition to amoxicillin (<jats:italic>n<\/jats:italic>\u2009=\u200944) and (iii) \u2018flare\u2019 where amoxicillin, used after DRESS onset, induced flare\u2010up reactions (<jats:italic>n<\/jats:italic>\u2009=\u200940). The median time to onset was 5\u2009days (IQR 2\u201311) in \u2018clear culprit\u2019, and 18\u2009days (IQR 7\u201326) in \u2018possible culprit\u2019 cases. In \u2018flare\u2019 cases, the median latency between amoxicillin initiation and flare\u2010up reactions was 3\u2009days (IQR 2\u20135).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Amoxicillin can induce DRESS with a specific early onset and exacerbate DRESS from another drug.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17631","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T08:37:06Z","timestamp":1630312626000},"page":"2415-2420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Specific features of amoxicillin\u2010associated Drug Reaction with Eosinophilia and Systemic Symptoms syndrome: a nationwide study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6824-7283","authenticated-orcid":false,"given":"B.","family":"Largeau","sequence":"first","affiliation":[{"name":"CHRU de Tours Service de 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