{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:50:00Z","timestamp":1788187800927,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cutaneous reactions, mostly on injection site after mRNA\u2010based COVID\u201019 vaccines, have been reported but not with detailed histopathological characterization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Characterization and classification of these reactions in a clinical and pathological point of view.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Monocentric case series of 11 patients with cutaneous manifestations, clinically and histologically characterized after COVID\u201019 vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From January to June 2021, we recorded 11 cutaneous reactions to mRNA COVID\u201019 vaccines from BNT162b2 (<jats:italic>n<\/jats:italic>\u2009=\u20098) and mRNA\u20101273 (<jats:italic>n<\/jats:italic>\u2009=\u20093). Generalized reactions showing erythematous rash or purpura were the most common clinical presentation, and drug\u2010reaction\u2010like pattern was the most common histological finding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A proper clinicopathological classification will be helpful in the early diagnosis and management of the cutaneous reactions to mRNA COVID\u201019 vaccines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17633","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T08:39:29Z","timestamp":1630312769000},"page":"2456-2461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Clinicopathological features of cutaneous reactions after mRNA\u2010based COVID\u201019 vaccines"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9314-4657","authenticated-orcid":false,"given":"M.","family":"Tihy","sequence":"first","affiliation":[{"name":"Department of Clinical Pathology University Hospital of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Menzinger","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology University Hospital of Geneva Geneva Switzerland"},{"name":"Department of Dermatology University Hospital of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8352-988X","authenticated-orcid":false,"given":"R.","family":"Andr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Laffitte","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Toutous\u2010Trellu","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology University Hospital of Geneva Geneva Switzerland"},{"name":"Department of Dermatology University Hospital of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035389"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.0600"},{"key":"e_1_2_6_5_1","first-page":"E1\u20133","article-title":"Acute allergic reactions to mRNA COVID\u201019 vaccines","volume":"3","author":"Blumenthal KG","year":"2021","journal-title":"JAMA"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.03.092"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2021.04.014"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17268"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2102131"},{"key":"e_1_2_6_10_1","first-page":"19","article-title":"Skin manifestations of the BNT162b2 mRNA COVID\u201019 vaccine in healthcare workers. \u2018COVID\u2010arm\u2019: a clinical and histological characterization","author":"Fernandez\u2010Nieto D","year":"2021","journal-title":"J Eur Acad Dermatology Venereol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17506"},{"key":"e_1_2_6_12_1","unstructured":"OFSP.OFSP\u2013 \u00c9tat: 25.05.2021. 2021."},{"key":"e_1_2_6_13_1","first-page":"1","article-title":"Vaccine side\u2010effects and SARS\u2010CoV\u20102 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study","volume":"3099","author":"Menni C","year":"2021","journal-title":"Lancet Infect Dis"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12942"}],"container-title":["Journal of the European Academy of Dermatology and 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