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This systematic review and meta\u2010analysis aimed to assess the prevalence of COVID\u201019 (diagnosed using PCR and\/or serology) in patients with CLL. We undertook a literature search in PubMed, Embase, and Scopus (to 15 March 2021), including studies that reported on the number of patients with CLL with positive PCR and\/or serology for severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) or with a clinical suspicion of COVID\u201019. Regardless of data heterogeneity, a random\u2010effects model was used to pool prevalence estimates. The meta\u2010analysis included 63 original studies, involving 2919 cases of CLL. A subgroup of these patients underwent diagnostic tests for COVID\u201019 (PCR: <jats:italic>n<\/jats:italic>\u2009=\u20091154, 39.5%; serology: <jats:italic>n<\/jats:italic>\u2009=\u2009943, 32.3%). The pooled prevalence of COVID\u201019 in the overall sample and in the subgroup who were tested for COVID\u201019 was, respectively: (i) positive PCR: 2.6% [95% confidence interval (CI) 1.9% to 3.4%] and 5.5% (95% CI, 3.7\u20137.7%); (ii) positive serology for SARS\u2010CoV\u20102: 7.2% (95% CI, 4.7\u201310.2%) and 11.8% (95% CI, 7.9\u201316.3%); and (iii) positive PCR and\/or serology, 15.2% (95% CI, 10.4\u201320.7%) and 7.5% (95% CI, 5.1\u201310.3%). Altogether, a small proportion of diagnostic tests for SARS\u2010CoV\u20102, both PCR and serologies, show positive results in patients with CLL.<\/jats:p>","DOI":"10.1111\/jdv.17672","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T08:46:21Z","timestamp":1632213981000},"page":"24-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Are the chilblain\u2010like lesions observed during the COVID\u201019 pandemic due to severe acute respiratory syndrome coronavirus 2? 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