{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:13:34Z","timestamp":1775664814035,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","award":["IN63214"],"award-info":[{"award-number":["IN63214"]}],"id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Enhancing the skin barrier in high\u2010risk neonates by daily use of emollients during infancy might prevent atopic dermatitis (AD); however, there have been no studies on this topic in a country with a tropical climate. Climate may affect the results of the use of emollients in neonates for AD prevention and possible adverse cutaneous eruptions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To test the hypothesis that emollients used during infancy can prevent AD in high\u2010risk neonates in a country with a tropical climate and to evaluate other possible adverse cutaneous eruptions in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomized controlled study in a tertiary care hospital with a 6\u2009months' duration. Eligible neonates were randomly assigned to receive either emollient and skincare advice (emollient group) or skincare advice only (control group). The intervention was started within 3\u2009weeks of birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The emollient group showed a significant reduction in the cumulative incidence of AD at 6\u2009months (relative risk, 0.39; 95% CI 0.24\u20130.64; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The emollient group started to develop AD later and had a lower severity of AD than the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Compared to moderate adherence, low adherence to emollient application was associated with a lower number of patients with AD (<jats:italic>P<\/jats:italic>\u2009=\u20090.008). Potentially emollient\u2010related cutaneous eruptions, such as miliaria, and suspected cutaneous infections, such as impetigo, were more frequent in the emollient group. Exposure to passive smoking showed a significant difference in the development of AD compared to non\u2010smoking exposure, both during pregnancy and after the child's birth (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that, in a tropical climate, emollient applied to the skin of at\u2010risk neonates on an \u2018as needed\u2019 basis (depending on environmental factors, level of skin dryness), rather than on a \u2018daily basis', can provide a substantial benefit for AD prevention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17675","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T08:45:45Z","timestamp":1632213945000},"page":"76-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effects of an emollient application on newborn skin from birth for prevention of atopic dermatitis: a randomized controlled study in Thai neonates"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4668-6792","authenticated-orcid":false,"given":"L.","family":"Techasatian","sequence":"first","affiliation":[{"name":"Pediatric Dermatology Division Pediatric Department Faculty of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Kiatchoosakun","sequence":"additional","affiliation":[{"name":"Neonatology Division Pediatric Department Faculty of Medicine Khon Kaen University Khon Kaen 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